AC   MF_01512;
DC   Protein; auto
TR   HAMAP; MF_01512; -; 1; level=0
XX
Names: FosB
XX
ID   FOSB
DE   RecName: Full=Metallothiol transferase FosB;
DE            EC=2.5.1.-;
DE   AltName: Full=Fosfomycin resistance protein;
GN   Name=fosB;
XX
CC   -!- FUNCTION: Metallothiol transferase which confers resistance to
CC       fosfomycin by catalyzing the addition of a thiol cofactor to
CC       fosfomycin. L-cysteine is probably the physiological thiol donor.
case <FTGroup:1>
CC   -!- COFACTOR:
CC       Name=Mg(2+); Xref=ChEBI:CHEBI:18420;
end case
CC   -!- SUBUNIT: Homodimer.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm.
CC   -!- SIMILARITY: Belongs to the fosfomycin resistance protein family. FosB
CC       subfamily.
XX
DR   Pfam; PF00903; Glyoxalase; 1; trigger=no
DR   PROSITE; PS51819; VOC; 1; trigger=yes
XX
KW   Cytoplasm
KW   Transferase
case <FTGroup:1>
KW   Magnesium
KW   Metal-binding
end case
KW   Antibiotic resistance
XX
case <FTGroup:1>
GO   GO:0000287; F:magnesium ion binding
end case
GO   GO:0016765; F:transferase activity, transferring alkyl or aryl (other than methyl) groups
GO   GO:0046677; P:response to antibiotic
GO   GO:0005737; C:cytoplasm
XX
FT   From: FOSB_BACSU (O31817)
FT   BINDING         8
FT                   /ligand="Mg(2+)"
FT                   /ligand_id="ChEBI:CHEBI:18420"
FT   Group: 1; Condition: H
FT   BINDING         67
FT                   /ligand="Mg(2+)"
FT                   /ligand_id="ChEBI:CHEBI:18420"
FT   Group: 1; Condition: H
FT   BINDING         116
FT                   /ligand="Mg(2+)"
FT                   /ligand_id="ChEBI:CHEBI:18420"
FT   Group: 1; Condition: E
XX
Size: 138-154;
Related: None;
Template: O31817; Q03377; Q56415;
Scope:
 Bacteria; Bacillales
Fusion:
 Nter: None
 Cter: None
Duplicate: in BACAN
Plasmid: in STAES, STAHA, STAHJ
Comments: None
XX
# Revision 1.21 2022/11/19
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