AC MF_01516; DC Protein; auto TR HAMAP; MF_01516; -; 1; level=0 XX Names: Malate_dehydrog_1 XX ID MDH DE RecName: Full=Malate dehydrogenase; DE EC=1.1.1.37; GN Name=mdh; XX CC -!- FUNCTION: Catalyzes the reversible oxidation of malate to oxaloacetate. CC -!- CATALYTIC ACTIVITY: CC Reaction=(S)-malate + NAD(+) = H(+) + NADH + oxaloacetate; CC Xref=Rhea:RHEA:21432, ChEBI:CHEBI:15378, ChEBI:CHEBI:15589, CC ChEBI:CHEBI:16452, ChEBI:CHEBI:57540, ChEBI:CHEBI:57945; EC=1.1.1.37; CC -!- SUBUNIT: Homodimer. CC -!- SIMILARITY: Belongs to the LDH/MDH superfamily. MDH type 1 family. XX DR Pfam; PF02866; Ldh_1_C; 1; trigger=no DR Pfam; PF00056; Ldh_1_N; 1; trigger=no DR NCBIfam; TIGR01772; MDH_euk_gproteo; 1; trigger=no DR PROSITE; PS00068; MDH; 1; trigger=no XX KW Oxidoreductase KW Tricarboxylic acid cycle KW NAD XX GO GO:0030060; F:L-malate dehydrogenase activity GO GO:0006099; P:tricarboxylic acid cycle XX FT From: MDH_ECOLI (P61889) FT BINDING 7..13 FT /ligand="NAD(+)" FT /ligand_id="ChEBI:CHEBI:57540" FT Condition: G-A-[AS]-G-G-I-G FT BINDING 117..119 FT /ligand="NAD(+)" FT /ligand_id="ChEBI:CHEBI:57540" FT Condition: [IV]-T-N FT ACT_SITE 177 FT /note="Proton acceptor" FT Condition: H FT BINDING 34 FT /ligand="NAD(+)" FT /ligand_id="ChEBI:CHEBI:57540" FT Condition: D FT BINDING 81 FT /ligand="substrate" FT Condition: R FT BINDING 87 FT /ligand="substrate" FT Condition: R FT BINDING 94 FT /ligand="NAD(+)" FT /ligand_id="ChEBI:CHEBI:57540" FT Condition: N FT BINDING 119 FT /ligand="substrate" FT Condition: N FT BINDING 153 FT /ligand="substrate" FT Condition: R FT BINDING 227 FT /ligand="NAD(+)" FT /ligand_id="ChEBI:CHEBI:57540" FT Condition: M XX Size: 310-324; Related: MF_00487; MF_00488; MF_01517; Template: P61889; Q7X3X5; P48364; Scope: Bacteria; Gammaproteobacteria Fusion: Nter: None Cter: None Duplicate: None Plasmid: None Comments: None XX # Revision 1.19 2023/06/01 //