AC   MF_01517;
DC   Protein; auto
TR   HAMAP; MF_01517; -; 1; level=0
XX
Names: Malate_dehydrog_2
XX
ID   MDH
DE   RecName: Full=Malate dehydrogenase;
DE            EC=1.1.1.37;
GN   Name=mdh;
XX
CC   -!- FUNCTION: Catalyzes the reversible oxidation of malate to oxaloacetate.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=(S)-malate + NAD(+) = H(+) + NADH + oxaloacetate;
CC         Xref=Rhea:RHEA:21432, ChEBI:CHEBI:15378, ChEBI:CHEBI:15589,
CC         ChEBI:CHEBI:16452, ChEBI:CHEBI:57540, ChEBI:CHEBI:57945; EC=1.1.1.37;
CC   -!- SIMILARITY: Belongs to the LDH/MDH superfamily. MDH type 2 family.
XX
DR   Pfam; PF02866; Ldh_1_C; 1; trigger=no
DR   Pfam; PF00056; Ldh_1_N; 1; trigger=no
DR   NCBIfam; TIGR01759; MalateDH-SF1; 1; trigger=no
DR   PROSITE; PS00068; MDH; 1; trigger=no
XX
KW   Oxidoreductase
KW   Tricarboxylic acid cycle
KW   NAD
XX
GO   GO:0030060; F:L-malate dehydrogenase activity
GO   GO:0006099; P:tricarboxylic acid cycle
XX
FT   From: MDH_THETH (P10584)
FT   BINDING         11..17
FT                   /ligand="NAD(+)"
FT                   /ligand_id="ChEBI:CHEBI:57540"
FT   Condition: G-[AG]-x-G-x-[IV]-[GACS]
FT   BINDING         129..131
FT                   /ligand="NAD(+)"
FT                   /ligand_id="ChEBI:CHEBI:57540"
FT   Condition: [VT]-G-N
FT   ACT_SITE        187
FT                   /note="Proton acceptor"
FT   Condition: H
FT   BINDING         92
FT                   /ligand="substrate"
FT   Condition: R
FT   BINDING         98
FT                   /ligand="substrate"
FT   Condition: R
FT   BINDING         105
FT                   /ligand="NAD(+)"
FT                   /ligand_id="ChEBI:CHEBI:57540"
FT   Condition: N
FT   BINDING         112
FT                   /ligand="NAD(+)"
FT                   /ligand_id="ChEBI:CHEBI:57540"
FT   Condition: Q
FT   BINDING         131
FT                   /ligand="substrate"
FT   Condition: N
FT   BINDING         162
FT                   /ligand="substrate"
FT   Condition: R
XX
Size: 310-375;
Related: MF_00487; MF_00488; MF_01516;
Template: P10584; Q8NN33; Q82HS2; Q9K3J3;
Scope:
 Bacteria
Fusion:
 Nter: None
 Cter: None
Duplicate: None
Plasmid: None
Comments: None
XX
# Revision 1.25 2023/06/01
//