AC   MF_01524;
DC   Protein; auto
TR   HAMAP; MF_01524; -; 1; level=0
XX
Names: CaiC
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ID   CAIC
DE   RecName: Full=Crotonobetaine/carnitine--CoA ligase;
DE            EC=6.2.1.48;
GN   Name=caiC;
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CC   -!- FUNCTION: Catalyzes the transfer of CoA to carnitine, generating the
CC       initial carnitinyl-CoA needed for the CaiB reaction cycle. Also has
CC       activity toward crotonobetaine and gamma-butyrobetaine.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=(R)-carnitine + ATP + CoA = (R)-carnitinyl-CoA + AMP +
CC         diphosphate; Xref=Rhea:RHEA:28514, ChEBI:CHEBI:16347,
CC         ChEBI:CHEBI:30616, ChEBI:CHEBI:33019, ChEBI:CHEBI:57287,
CC         ChEBI:CHEBI:60932, ChEBI:CHEBI:456215; EC=6.2.1.48;
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=crotonobetaine + ATP + CoA = crotonobetainyl-CoA + AMP +
CC         diphosphate; Xref=Rhea:RHEA:30079, ChEBI:CHEBI:17237,
CC         ChEBI:CHEBI:30616, ChEBI:CHEBI:33019, ChEBI:CHEBI:57287,
CC         ChEBI:CHEBI:60933, ChEBI:CHEBI:456215;
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=4-(trimethylamino)butanoate + ATP + CoA = 4-
CC         (trimethylamino)butanoyl-CoA + AMP + diphosphate;
CC         Xref=Rhea:RHEA:55960, ChEBI:CHEBI:16244, ChEBI:CHEBI:30616,
CC         ChEBI:CHEBI:33019, ChEBI:CHEBI:57287, ChEBI:CHEBI:61513,
CC         ChEBI:CHEBI:456215;
CC   -!- PATHWAY: Amine and polyamine metabolism; carnitine metabolism.
CC   -!- SIMILARITY: Belongs to the ATP-dependent AMP-binding enzyme family.
XX
DR   Pfam; PF00501; AMP-binding; 1; trigger=no
DR   PRINTS; PR00154; AMPBINDING; 1; trigger=no
DR   PROSITE; PS00455; AMP_BINDING; 1; trigger=no
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KW   Ligase
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GO   GO:0016405; F:CoA-ligase activity
GO   GO:0009437; P:carnitine metabolic process
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FT   None
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Size: 510-518;
Related: None;
Template: P31552;
Scope:
 Bacteria; Enterobacterales
Fusion:
 Nter: None
 Cter: None
Duplicate: None
Plasmid: None
Comments: None
XX
# Version: 18
# Last updated date: 2024-09-03
# Created date: 2005-02-28
//