AC   MF_01529;
DC   Protein; auto
TR   HAMAP; MF_01529; -; 1; level=0
XX
Names: MFS_MdtH
XX
ID   MDTH
DE   RecName: Full=Multidrug resistance protein MdtH;
GN   Name=mdtH;
XX
case <OC:Escherichia>
CC   -!- FUNCTION: Confers resistance to norfloxacin and enoxacin.
end case
case not defined <Property:Membrane> or <Property:Membrane=1>
CC   -!- SUBCELLULAR LOCATION: Cell membrane; Multi-pass membrane protein.
else case <Property:Membrane=2>
CC   -!- SUBCELLULAR LOCATION: Cell inner membrane; Multi-pass membrane protein.
end case
CC   -!- SIMILARITY: Belongs to the major facilitator superfamily. DHA1 family.
CC       MdtH (TC 2.A.1.2.21) subfamily.
XX
DR   Pfam; PF07690; MFS_1; 1; trigger=no
DR   PROSITE; PS50850; MFS; 1; trigger=no
case not <OC:Escherichia> and not <OC:Shigella> and not <OC:Salmonella>
DR   General; Transmembrane; -; 10-12; trigger=yes
end case
XX
case <OC:Escherichia>
KW   Antibiotic resistance
end case
KW   Cell membrane
case defined <Property:Membrane> and <Property:Membrane=2>
KW   Cell inner membrane
end case
KW   Membrane
KW   Transmembrane
KW   Transport
KW   Transmembrane helix
XX
GO   GO:0022857; F:transmembrane transporter activity
GO   GO:0055085; P:transmembrane transport
GO   GO:0005886; C:plasma membrane
XX
FT   From: MDTH_ECOLI (P69367)
case <OC:Escherichia> or <OC:Shigella> or <OC:Salmonella>
FT   TOPO_DOM        Nter..12
FT                   /note="Cytoplasmic"
FT   TRANSMEM        13..33
FT                   /note="Helical"
FT   TOPO_DOM        34..98
FT                   /note="Periplasmic"
FT   TRANSMEM        99..116
FT                   /note="Helical"
FT   TOPO_DOM        117..138
FT                   /note="Cytoplasmic"
FT   TRANSMEM        139..159
FT                   /note="Helical"
FT   TOPO_DOM        160..164
FT                   /note="Periplasmic"
FT   TRANSMEM        165..185
FT                   /note="Helical"
FT   TOPO_DOM        186..213
FT                   /note="Cytoplasmic"
FT   TRANSMEM        214..234
FT                   /note="Helical"
FT   TOPO_DOM        235..243
FT                   /note="Periplasmic"
FT   TRANSMEM        244..264
FT                   /note="Helical"
FT   TOPO_DOM        265..276
FT                   /note="Cytoplasmic"
FT   TRANSMEM        277..297
FT                   /note="Helical"
FT   TOPO_DOM        298..299
FT                   /note="Periplasmic"
FT   TRANSMEM        300..320
FT                   /note="Helical"
FT   TOPO_DOM        321..339
FT                   /note="Cytoplasmic"
FT   TRANSMEM        340..360
FT                   /note="Helical"
FT   TOPO_DOM        361..367
FT                   /note="Periplasmic"
FT   TRANSMEM        368..388
FT                   /note="Helical"
FT   TOPO_DOM        389..Cter
FT                   /note="Cytoplasmic"
end case
XX
Size: 397-411;
Related: None;
Template: P69367;
Scope:
 Bacteria; Gammaproteobacteria
Fusion:
 Nter: None
 Cter: None
Duplicate: None
Plasmid: None
Comments: None
XX
# Revision 1.26 2019/11/19
//