AC   MF_01543;
DC   Protein; auto
TR   HAMAP; MF_01543; -; 1; level=0
XX
Names: FTHFS
XX
ID   FTHS
DE   RecName: Full=Formate--tetrahydrofolate ligase;
DE            EC=6.3.4.3;
DE   AltName: Full=Formyltetrahydrofolate synthetase;
DE            Short=FHS;
DE            Short=FTHFS;
GN   Name=fhs;
XX
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=(6S)-5,6,7,8-tetrahydrofolate + ATP + formate = (6R)-10-
CC         formyltetrahydrofolate + ADP + phosphate; Xref=Rhea:RHEA:20221,
CC         ChEBI:CHEBI:15740, ChEBI:CHEBI:30616, ChEBI:CHEBI:43474,
CC         ChEBI:CHEBI:57453, ChEBI:CHEBI:195366, ChEBI:CHEBI:456216;
CC         EC=6.3.4.3;
CC   -!- PATHWAY: One-carbon metabolism; tetrahydrofolate interconversion.
CC   -!- SIMILARITY: Belongs to the formate--tetrahydrofolate ligase family.
XX
DR   PROSITE; PS00721; FTHFS_1; 1; trigger=no
DR   PROSITE; PS00722; FTHFS_2; 1; trigger=no
DR   Pfam; PF01268; FTHFS; 1; trigger=no
XX
KW   ATP-binding
KW   Ligase
KW   Nucleotide-binding
KW   One-carbon metabolism
XX
GO   GO:0004329; F:formate-tetrahydrofolate ligase activity
GO   GO:0005524; F:ATP binding
GO   GO:0006730; P:one-carbon metabolic process
XX
FT   From: FTHS_MOOTH (P21164)
FT   BINDING         68..75
FT                   /ligand="ATP"
FT                   /ligand_id="ChEBI:CHEBI:30616"
FT   Condition: [TS]-x-x-G-[EIV]-G-K-[TS]
XX
Size: 505-597;
Related: None;
Template: P21164; Q83WS0;
Scope:
 Bacteria
 Archaea; Euryarchaeota
Fusion:
 Nter: None
 Cter: None
Duplicate: in DEHM1, DESHY, LACAC, PARDP, RUBXD, RUEPO, STRP1, STRP3, STRP6,
 STRP8, STRPB, STRPC, STRPD, STRPF, STRPG, STRPM, STRSV
Plasmid: in HALMA
Comments: None
XX
# Revision 1.23 2023/07/18
//