AC   MF_01547;
DC   Protein; auto
c?   <OC:Bacteria> or <OC:Archaea>
TR   HAMAP; MF_01547; -; 1; level=0
XX
Names: RNA_methyltr_E
XX
ID   RLME
DE   RecName: Full=Ribosomal RNA large subunit methyltransferase E;
DE            EC=2.1.1.166;
DE   AltName: Full=23S rRNA Um2552 methyltransferase;
DE   AltName: Full=rRNA (uridine-2'-O-)-methyltransferase;
case <OC:Bacteria>
GN   Name=rlmE; Synonyms=ftsJ, rrmJ;
else case <OC:Archaea>
GN   Name=rlmE;
end case
XX
CC   -!- FUNCTION: Specifically methylates the uridine in position 2552 of 23S
CC       rRNA at the 2'-O position of the ribose in the fully assembled 50S
CC       ribosomal subunit.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=S-adenosyl-L-methionine + uridine(2552) in 23S rRNA = 2'-O-
CC         methyluridine(2552) in 23S rRNA + H(+) + S-adenosyl-L-homocysteine;
CC         Xref=Rhea:RHEA:42720, Rhea:RHEA-COMP:10202, Rhea:RHEA-COMP:10203,
CC         ChEBI:CHEBI:15378, ChEBI:CHEBI:57856, ChEBI:CHEBI:59789,
CC         ChEBI:CHEBI:65315, ChEBI:CHEBI:74478; EC=2.1.1.166;
CC   -!- SUBCELLULAR LOCATION: Cytoplasm.
CC   -!- SIMILARITY: Belongs to the class I-like SAM-binding methyltransferase
CC       superfamily. RNA methyltransferase RlmE family.
XX
DR   PROSITE; PS50926; TRAM; 0-1; trigger=yes
DR   Pfam; PF01728; FtsJ; 1; trigger=no
DR   Pfam; PF01938; TRAM; 0-1; trigger=no
DR   PIRSF; PIRSF005461; 23S_rRNA_mtase; 1; trigger=no
DR   NCBIfam; TIGR00438; RrmJ; 1; trigger=no
XX
KW   Cytoplasm
KW   Methyltransferase
KW   rRNA processing
KW   S-adenosyl-L-methionine
KW   Transferase
XX
GO   GO:0008650; F:rRNA (uridine-2'-O-)-methyltransferase activity
GO   GO:0006364; P:rRNA processing
GO   GO:0005737; C:cytoplasm
XX
FT   From: RLME_ECOLI (P0C0R7)
FT   ACT_SITE        164
FT                   /note="Proton acceptor"
FT   Condition: K
FT   BINDING         63
FT                   /ligand="S-adenosyl-L-methionine"
FT                   /ligand_id="ChEBI:CHEBI:59789"
FT   Group: 1; Condition: G
FT   BINDING         65
FT                   /ligand="S-adenosyl-L-methionine"
FT                   /ligand_id="ChEBI:CHEBI:59789"
FT   Group: 1; Condition: [WF]
FT   BINDING         83
FT                   /ligand="S-adenosyl-L-methionine"
FT                   /ligand_id="ChEBI:CHEBI:59789"
FT   Group: 1; Condition: D
FT   BINDING         99
FT                   /ligand="S-adenosyl-L-methionine"
FT                   /ligand_id="ChEBI:CHEBI:59789"
FT   Group: 1; Condition: [DN]
FT   BINDING         124
FT                   /ligand="S-adenosyl-L-methionine"
FT                   /ligand_id="ChEBI:CHEBI:59789"
FT   Group: 1; Condition: D
XX
Size: 189-279;
Related: MF_03162!; MF_03163!;
Template: P0C0R7;
Scope:
 Bacteria
 Archaea
Fusion:
 Nter: None
 Cter: None
Duplicate: None
Plasmid: None
Comments: None
XX
# Revision 1.28 2023/06/01
//