AC   MF_01550;
DC   Protein; auto
TR   HAMAP; MF_01550; -; 1; level=0
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Names: GppA
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ID   GPPA
DE   RecName: Full=Guanosine-5'-triphosphate,3'-diphosphate pyrophosphatase;
DE            EC=3.6.1.40;
DE   AltName: Full=Guanosine pentaphosphate phosphohydrolase;
DE   AltName: Full=pppGpp-5'-phosphohydrolase;
GN   Name=gppA;
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CC   -!- FUNCTION: Catalyzes the conversion of pppGpp to ppGpp. Guanosine
CC       pentaphosphate (pppGpp) is a cytoplasmic signaling molecule which
CC       together with ppGpp controls the 'stringent response', an adaptive
CC       process that allows bacteria to respond to amino acid starvation,
CC       resulting in the coordinated regulation of numerous cellular
CC       activities.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=guanosine 3'-diphosphate 5'-triphosphate + H2O = guanosine
CC         3',5'-bis(diphosphate) + H(+) + phosphate; Xref=Rhea:RHEA:13073,
CC         ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:43474,
CC         ChEBI:CHEBI:77828, ChEBI:CHEBI:142410; EC=3.6.1.40;
CC   -!- PATHWAY: Purine metabolism; ppGpp biosynthesis; ppGpp from GTP: step
CC       2/2.
CC   -!- SIMILARITY: Belongs to the GppA/Ppx family. GppA subfamily.
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DR   Pfam; PF02541; Ppx-GppA; 1; trigger=no
DR   PIRSF; PIRSF001267; Pyrophosphatase_GppA_Ppx; 1; trigger=no
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KW   Hydrolase
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GO   GO:0008894; F:guanosine-5'-triphosphate,3'-diphosphate diphosphatase activity
GO   GO:0015974; P:guanosine pentaphosphate catabolic process
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Size: 475-525;
Related: None;
Template: P25552;
Scope:
 Bacteria; Gammaproteobacteria
Fusion:
 Nter: None
 Cter: None
Duplicate: None
Plasmid: None
Comments: None
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# Revision 1.15 2019/11/19
//