AC   MF_01551;
DC   Protein; auto
TR   HAMAP; MF_01551; -; 1; level=0
XX
Names: 23SrRNA_methyltr_M
XX
ID   RLMM
DE   RecName: Full=Ribosomal RNA large subunit methyltransferase M;
DE            EC=2.1.1.186;
DE   AltName: Full=23S rRNA (cytidine2498-2'-O)-methyltransferase;
DE   AltName: Full=23S rRNA 2'-O-ribose methyltransferase RlmM;
GN   Name=rlmM;
XX
CC   -!- FUNCTION: Catalyzes the 2'-O-methylation at nucleotide C2498 in 23S
CC       rRNA.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=cytidine(2498) in 23S rRNA + S-adenosyl-L-methionine = 2'-O-
CC         methylcytidine(2498) in 23S rRNA + H(+) + S-adenosyl-L-homocysteine;
CC         Xref=Rhea:RHEA:42788, Rhea:RHEA-COMP:10244, Rhea:RHEA-COMP:10245,
CC         ChEBI:CHEBI:15378, ChEBI:CHEBI:57856, ChEBI:CHEBI:59789,
CC         ChEBI:CHEBI:74495, ChEBI:CHEBI:82748; EC=2.1.1.186;
CC   -!- SUBUNIT: Monomer.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm.
CC   -!- SIMILARITY: Belongs to the class I-like SAM-binding methyltransferase
CC       superfamily. RNA methyltransferase RlmE family. RlmM subfamily.
XX
DR   Pfam; PF01728; FtsJ; 1; trigger=no
DR   PIRSF; PIRSF028774; UCP028774; 1; trigger=no
XX
KW   Cytoplasm
KW   Methyltransferase
KW   rRNA processing
KW   S-adenosyl-L-methionine
KW   Transferase
XX
GO   GO:0008757; F:S-adenosylmethionine-dependent methyltransferase activity
GO   GO:0006364; P:rRNA processing
GO   GO:0005737; C:cytoplasm
XX
FT   From: RLMM_ECOLI (P0ADR6)
FT   ACT_SITE        306
FT                   /note="Proton acceptor"
FT   Condition: K
FT   BINDING         221..224
FT                   /ligand="S-adenosyl-L-methionine"
FT                   /ligand_id="ChEBI:CHEBI:59789"
FT   Condition: [CSA]-P-G-G
FT   BINDING         188
FT                   /ligand="S-adenosyl-L-methionine"
FT                   /ligand_id="ChEBI:CHEBI:59789"
FT   Condition: S
FT   BINDING         240
FT                   /ligand="S-adenosyl-L-methionine"
FT                   /ligand_id="ChEBI:CHEBI:59789"
FT   Condition: D
FT   BINDING         260
FT                   /ligand="S-adenosyl-L-methionine"
FT                   /ligand_id="ChEBI:CHEBI:59789"
FT   Condition: D
FT   BINDING         277
FT                   /ligand="S-adenosyl-L-methionine"
FT                   /ligand_id="ChEBI:CHEBI:59789"
FT   Condition: D
XX
Size: 339-389;
Related: None;
Template: P0ADR6;
Scope:
 Bacteria; Pseudomonadota
Fusion:
 Nter: None
 Cter: None
Duplicate: None
Plasmid: None
Comments: None
XX
# Revision 1.21 2023/01/26
//