AC   MF_01558;
DC   Protein; auto
TR   HAMAP; MF_01558; -; 1; level=0
XX
Names: Cyt_deam
XX
ID   CDD
DE   RecName: Full=Cytidine deaminase;
DE            EC=3.5.4.5;
DE   AltName: Full=Cytidine aminohydrolase;
DE            Short=CDA;
GN   Name=cdd;
XX
CC   -!- FUNCTION: This enzyme scavenges exogenous and endogenous cytidine and
CC       2'-deoxycytidine for UMP synthesis.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=cytidine + H(+) + H2O = NH4(+) + uridine;
CC         Xref=Rhea:RHEA:16069, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378,
CC         ChEBI:CHEBI:16704, ChEBI:CHEBI:17562, ChEBI:CHEBI:28938; EC=3.5.4.5;
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=2'-deoxycytidine + H(+) + H2O = 2'-deoxyuridine + NH4(+);
CC         Xref=Rhea:RHEA:13433, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378,
CC         ChEBI:CHEBI:15698, ChEBI:CHEBI:16450, ChEBI:CHEBI:28938; EC=3.5.4.5;
case <FTGroup:1>
CC   -!- COFACTOR:
CC       Name=Zn(2+); Xref=ChEBI:CHEBI:29105;
CC       Note=Binds 1 zinc ion.;
end case
CC   -!- SUBUNIT: Homodimer.
CC   -!- SIMILARITY: Belongs to the cytidine and deoxycytidylate deaminase
CC       family.
XX
DR   Pfam; PF00383; dCMP_cyt_deam_1; 1; trigger=no
DR   Pfam; PF08211; dCMP_cyt_deam_2; 1; trigger=no
DR   NCBIfam; TIGR01355; Cyt_deam_dimer; 1; trigger=no
DR   PROSITE; PS00903; CYT_DCMP_DEAMINASES_1; 1; trigger=no
DR   PROSITE; PS51747; CYT_DCMP_DEAMINASES_2; 2; trigger=yes
XX
KW   Hydrolase
case <FTGroup:1>
KW   Metal-binding
KW   Zinc
end case
XX
GO   GO:0004126; F:cytidine deaminase activity
case <FTGroup:1>
GO   GO:0008270; F:zinc ion binding
end case
XX
FT   From: CDD_ECOLI (P0ABF6)
FT   BINDING         89..91
FT                   /ligand="substrate"
FT   Condition: N-x-E
FT   ACT_SITE        104
FT                   /note="Proton donor"
FT   Condition: E
FT   BINDING         102
FT                   /ligand="Zn(2+)"
FT                   /ligand_id="ChEBI:CHEBI:29105"
FT                   /ligand_note="catalytic"
FT   Group: 1; Condition: H
FT   BINDING         129
FT                   /ligand="Zn(2+)"
FT                   /ligand_id="ChEBI:CHEBI:29105"
FT                   /ligand_note="catalytic"
FT   Group: 1; Condition: C
FT   BINDING         132
FT                   /ligand="Zn(2+)"
FT                   /ligand_id="ChEBI:CHEBI:29105"
FT                   /ligand_note="catalytic"
FT   Group: 1; Condition: C
XX
Size: 292-309;
Related: None;
Template: P0ABF6;
Scope:
 Bacteria; Gammaproteobacteria
Fusion:
 Nter: None
 Cter: None
Duplicate: None
Plasmid: None
Comments: None
XX
# Revision 1.21 2023/06/01
//