AC   MF_01573;
DC   Protein; auto
TR   HAMAP; MF_01573; -; 1; level=0
XX
Names: Pyl_tRNA_synth
XX
ID   PYLS
DE   RecName: Full=Pyrrolysine--tRNA ligase;
DE            EC=6.1.1.26;
DE   AltName: Full=Pyrrolysyl-tRNA synthetase;
DE            Short=PylRS;
GN   Name=pylS;
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CC   -!- FUNCTION: Catalyzes the attachment of pyrrolysine to tRNA(Pyl).
CC       Pyrrolysine is a lysine derivative encoded by the termination codon
CC       UAG.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=ATP + L-pyrrolysine + tRNA(Pyl) = AMP + diphosphate + L-
CC         pyrrolysyl-tRNA(Pyl); Xref=Rhea:RHEA:19277, Rhea:RHEA-COMP:9720,
CC         Rhea:RHEA-COMP:9721, ChEBI:CHEBI:30616, ChEBI:CHEBI:33019,
CC         ChEBI:CHEBI:58499, ChEBI:CHEBI:78442, ChEBI:CHEBI:78556,
CC         ChEBI:CHEBI:456215; EC=6.1.1.26;
CC   -!- SUBCELLULAR LOCATION: Cytoplasm.
CC   -!- SIMILARITY: Belongs to the class-II aminoacyl-tRNA synthetase family.
XX
DR   PROSITE; PS50862; AA_TRNA_LIGASE_II; 1; trigger=no
DR   Pfam; PF00587; tRNA-synt_2b; 1; trigger=no
DR   NCBIfam; TIGR02367; PylS_Cterm; 1; trigger=no
DR   NCBIfam; TIGR03912; PylS_Nterm; 1; trigger=no
XX
KW   Cytoplasm
KW   Aminoacyl-tRNA synthetase
KW   ATP-binding
KW   Ligase
KW   Nucleotide-binding
KW   Protein biosynthesis
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GO   GO:0004812; F:aminoacyl-tRNA ligase activity
GO   GO:0005524; F:ATP binding
GO   GO:0006418; P:tRNA aminoacylation for protein translation
GO   GO:0005737; C:cytoplasm
XX
Size: 404-478;
Related: None;
Template: Q6WRH6; Q46E77;
Scope:
 Archaea; Methanosarcinales
Fusion:
 Nter: None
 Cter: None
Duplicate: None
Plasmid: None
Comments: None
XX
# Revision 1.15 2023/06/01
//