AC   MF_01576;
DC   Protein; auto
TR   HAMAP; MF_01576; -; 1; level=0
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Names: THF_DHG_CYH
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ID   FOLD
DE   RecName: Full=Bifunctional protein FolD;
DE   Includes:
DE     RecName: Full=Methylenetetrahydrofolate dehydrogenase;
DE              EC=1.5.1.5;
DE   Includes:
DE     RecName: Full=Methenyltetrahydrofolate cyclohydrolase;
DE              EC=3.5.4.9;
GN   Name=folD;
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CC   -!- FUNCTION: Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to
CC       5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-
CC       methenyltetrahydrofolate to 10-formyltetrahydrofolate.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=(6R)-5,10-methylene-5,6,7,8-tetrahydrofolate + NADP(+) = (6R)-
CC         5,10-methenyltetrahydrofolate + NADPH; Xref=Rhea:RHEA:22812,
CC         ChEBI:CHEBI:15636, ChEBI:CHEBI:57455, ChEBI:CHEBI:57783,
CC         ChEBI:CHEBI:58349; EC=1.5.1.5;
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=(6R)-5,10-methenyltetrahydrofolate + H2O = (6R)-10-
CC         formyltetrahydrofolate + H(+); Xref=Rhea:RHEA:23700,
CC         ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:57455,
CC         ChEBI:CHEBI:195366; EC=3.5.4.9;
CC   -!- PATHWAY: One-carbon metabolism; tetrahydrofolate interconversion.
CC   -!- SUBUNIT: Homodimer.
CC   -!- SIMILARITY: Belongs to the tetrahydrofolate
CC       dehydrogenase/cyclohydrolase family.
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DR   PROSITE; PS00766; THF_DHG_CYH_1; 1; trigger=no
DR   PROSITE; PS00767; THF_DHG_CYH_2; 1; trigger=no
DR   Pfam; PF00763; THF_DHG_CYH; 1; trigger=no
DR   Pfam; PF02882; THF_DHG_CYH_C; 1; trigger=no
DR   PRINTS; PR00085; THFDHDRGNASE; 1; trigger=no
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KW   Amino-acid biosynthesis
KW   Histidine biosynthesis
KW   Hydrolase
KW   Methionine biosynthesis
KW   Multifunctional enzyme
KW   NADP
KW   One-carbon metabolism
KW   Oxidoreductase
KW   Purine biosynthesis
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GO   GO:0004477; F:methenyltetrahydrofolate cyclohydrolase activity
GO   GO:0004488; F:methylenetetrahydrofolate dehydrogenase (NADP+) activity
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FT   From: FOLD_THEAC (Q05213)
FT   BINDING         157..159
FT                   /ligand="NADP(+)"
FT                   /ligand_id="ChEBI:CHEBI:58349"
FT   Condition: [GN]-x-[SG]
FT   BINDING         182
FT                   /ligand="NADP(+)"
FT                   /ligand_id="ChEBI:CHEBI:58349"
FT   Optional; Condition: [ST]
FT   BINDING         182
FT                   /ligand="NADP(+)"
FT                   /ligand_id="ChEBI:CHEBI:58349"
FT   Optional; Condition: I
FT   BINDING         223
FT                   /ligand="NADP(+)"
FT                   /ligand_id="ChEBI:CHEBI:58349"
FT   Optional; Condition: [IVAT]
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Size: 269-320;
Related: None;
Template: P24186; P51696; Q05213; Q9I2U6; Q0PA35; Q5NGF3; P9WG81;
Scope:
 Bacteria
 Archaea
Fusion:
 Nter: None
 Cter: None
Duplicate: in ACIAD, PAEAT, BORPA, BORPE, COLP3, DEHM1, DEIGD, DESHY, FRAAA,
 FRACC, GEOMG, GEOSL, HALMA, LACH4, LACJO, MYXXD, NOCSJ, PARDP, PSE14, PSEMY,
 PSEPG, PSEPK, PSESM, PSEU2, RHIEC, RHILO, RHIME, RHOJR, ROSDO, RUBXD, SACEN,
 SALAI, SALTO, RUEPO, SINMW, RHIWR, STRAW, SYNWW, HYDCU
Plasmid: in HALMA, PARDP, RHIEC, SINFN
Comments: None
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# Revision 1.27 2023/11/29
//