AC   MF_01587;
DC   Protein; auto
TR   HAMAP; MF_01587; -; 1; level=0
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Names: DNA_ligase_B
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ID   LIGB
DE   RecName: Full=DNA ligase B;
DE            EC=6.5.1.2;
DE   AltName: Full=Polydeoxyribonucleotide synthase [NAD(+)] B;
GN   Name=ligB;
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CC   -!- FUNCTION: Catalyzes the formation of phosphodiester linkages between
CC       5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD
CC       as a coenzyme and as the energy source for the reaction.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=NAD(+) + (deoxyribonucleotide)n-3'-hydroxyl + 5'-phospho-
CC         (deoxyribonucleotide)m = (deoxyribonucleotide)n+m + AMP + beta-
CC         nicotinamide D-nucleotide.; EC=6.5.1.2;
CC   -!- SIMILARITY: Belongs to the NAD-dependent DNA ligase family. LigB
CC       subfamily.
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DR   PROSITE; PS01055; DNA_LIGASE_N1; 1; trigger=no
DR   PROSITE; PS01056; DNA_LIGASE_N2; 1; trigger=no
DR   Pfam; PF01653; DNA_ligase_aden; 1; trigger=no
DR   Pfam; PF03120; DNA_ligase_OB; 1; trigger=no
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KW   DNA damage
KW   DNA repair
KW   DNA replication
KW   Ligase
KW   NAD
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GO   GO:0003911; F:DNA ligase (NAD+) activity
GO   GO:0006259; P:DNA metabolic process
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FT   From: LIGB_ECOLI (P25772)
FT   ACT_SITE        124
FT                   /note="N6-AMP-lysine intermediate"
FT   Condition: K
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Size: 554-629;
Related: MF_01588;
Template: P25772;
Scope:
 Bacteria; Gammaproteobacteria
Fusion:
 Nter: None
 Cter: None
Duplicate: None
Plasmid: None
Comments: None
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# Revision 1.14 2022/04/28
//