AC   MF_01590;
DC   Protein; auto
TR   HAMAP; MF_01590; -; 1; level=0
XX
Names: tRNA_carboxymethyltr_CmoB
XX
ID   CMOB
DE   RecName: Full=tRNA U34 carboxymethyltransferase;
DE            EC=2.5.1.-;
GN   Name=cmoB;
XX
CC   -!- FUNCTION: Catalyzes carboxymethyl transfer from carboxy-S-adenosyl-L-
CC       methionine (Cx-SAM) to 5-hydroxyuridine (ho5U) to form 5-
CC       carboxymethoxyuridine (cmo5U) at position 34 in tRNAs.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=5-hydroxyuridine(34) in tRNA + carboxy-S-adenosyl-L-methionine
CC         = 5-carboxymethoxyuridine(34) in tRNA + H(+) + S-adenosyl-L-
CC         homocysteine; Xref=Rhea:RHEA:52848, Rhea:RHEA-COMP:13381, Rhea:RHEA-
CC         COMP:13383, ChEBI:CHEBI:15378, ChEBI:CHEBI:57856, ChEBI:CHEBI:134278,
CC         ChEBI:CHEBI:136877, ChEBI:CHEBI:136879;
case <OC:Pseudomonadota>
CC   -!- SUBUNIT: Homotetramer.
end case
CC   -!- SIMILARITY: Belongs to the class I-like SAM-binding methyltransferase
CC       superfamily. CmoB family.
XX
DR   Pfam; PF08003; Methyltransf_9; 1; trigger=no
DR   NCBIfam; TIGR00452; TIGR00452; 1; trigger=no
XX
KW   Transferase
KW   tRNA processing
XX
GO   GO:0016765; F:transferase activity, transferring alkyl or aryl (other than methyl) groups
GO   GO:0006400; P:tRNA modification
XX
FT   From: CMOB_ECOLI (P76291)
FT   BINDING         152..154
FT                   /ligand="carboxy-S-adenosyl-L-methionine"
FT                   /ligand_id="ChEBI:CHEBI:134278"
FT   Optional; Condition: [DE]-P-[TS]
FT   BINDING         181..182
FT                   /ligand="carboxy-S-adenosyl-L-methionine"
FT                   /ligand_id="ChEBI:CHEBI:134278"
FT   Optional; Condition: [IVLM]-[ED]
FT   BINDING         91
FT                   /ligand="carboxy-S-adenosyl-L-methionine"
FT                   /ligand_id="ChEBI:CHEBI:134278"
FT   Optional; Condition: K
FT   BINDING         105
FT                   /ligand="carboxy-S-adenosyl-L-methionine"
FT                   /ligand_id="ChEBI:CHEBI:134278"
FT   Optional; Condition: W
FT   BINDING         110
FT                   /ligand="carboxy-S-adenosyl-L-methionine"
FT                   /ligand_id="ChEBI:CHEBI:134278"
FT   Optional; Condition: K
FT   BINDING         130
FT                   /ligand="carboxy-S-adenosyl-L-methionine"
FT                   /ligand_id="ChEBI:CHEBI:134278"
FT   Optional; Condition: G
FT   BINDING         196
FT                   /ligand="carboxy-S-adenosyl-L-methionine"
FT                   /ligand_id="ChEBI:CHEBI:134278"
FT   Optional; Condition: M
FT   BINDING         200
FT                   /ligand="carboxy-S-adenosyl-L-methionine"
FT                   /ligand_id="ChEBI:CHEBI:134278"
FT   Optional; Condition: Y
FT   BINDING         315
FT                   /ligand="carboxy-S-adenosyl-L-methionine"
FT                   /ligand_id="ChEBI:CHEBI:134278"
FT   Optional; Condition: R
XX
Size: 261-363;
Related: None;
Template: P76291; Q8ZNV1;
Scope:
 Bacteria; Oscillatoriales
 Bacteria; Pseudomonadota
Fusion:
 Nter: None
 Cter: None
Duplicate: None
Plasmid: None
Comments: None
XX
# Revision 1.15 2023/06/01
//