AC   MF_01593;
DC   Protein; auto
TR   HAMAP; MF_01593; -; 1; level=0
XX
Names: MtfA
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ID   MTFA
DE   RecName: Full=Mlc titration factor A;
DE   AltName: Full=Probable zinc metallopeptidase MtfA;
DE            EC=3.4.11.-;
GN   Name=mtfA;
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CC   -!- FUNCTION: Involved in the modulation of the activity of the glucose-
CC       phosphotransferase system (glucose-PTS). Interacts with the
CC       transcriptional repressor Mlc, preventing its interaction with DNA and
CC       leading to the modulation of expression of genes regulated by Mlc,
CC       including ptsG, which encodes the PTS system glucose-specific EIICB
CC       component.
CC   -!- FUNCTION: Shows zinc-dependent metallopeptidase activity.
CC   -!- COFACTOR:
CC       Name=Zn(2+); Xref=ChEBI:CHEBI:29105;
CC       Note=Binds 1 zinc ion per subunit.;
CC   -!- SUBUNIT: Interacts with Mlc.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm.
CC   -!- SIMILARITY: Belongs to the MtfA family.
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DR   Pfam; PF06167; Peptidase_M90; 1; trigger=no
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KW   Cytoplasm
KW   Hydrolase
KW   Protease
KW   Aminopeptidase
KW   Metal-binding
KW   Metalloprotease
KW   Zinc
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GO   GO:0004177; F:aminopeptidase activity
GO   GO:0008237; F:metallopeptidase activity
GO   GO:0008270; F:zinc ion binding
GO   GO:0005737; C:cytoplasm
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FT   From: MTFA_KLEP7 (A6TB83)
FT   BINDING         111
FT                   /ligand="Zn(2+)"
FT                   /ligand_id="ChEBI:CHEBI:29105"
FT   Condition: H
FT   BINDING         148
FT                   /ligand="Zn(2+)"
FT                   /ligand_id="ChEBI:CHEBI:29105"
FT   Condition: H
FT   BINDING         152
FT                   /ligand="Zn(2+)"
FT                   /ligand_id="ChEBI:CHEBI:29105"
FT   Condition: H
FT   BINDING         211
FT                   /ligand="Zn(2+)"
FT                   /ligand_id="ChEBI:CHEBI:29105"
FT   Condition: E
XX
XX
Size: 251-270;
Related: None;
Template: P76346; A6TB83;
Scope:
 Bacteria; Enterobacterales
Fusion:
 Nter: None
 Cter: None
Duplicate: None
Plasmid: None
Comments: None
XX
# Revision 1.13 2023/10/18
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