AC MF_01594; DC Protein; auto TR HAMAP; MF_01594; -; 1; level=0 XX Names: Rhomboid_GlpG XX ID GLPG DE RecName: Full=Rhomboid protease GlpG; DE EC=3.4.21.105; DE AltName: Full=Intramembrane serine protease; GN Name=glpG; XX CC -!- FUNCTION: Rhomboid-type serine protease that catalyzes intramembrane CC proteolysis. CC -!- CATALYTIC ACTIVITY: CC Reaction=Cleaves type-1 transmembrane domains using a catalytic dyad CC composed of serine and histidine that are contributed by different CC transmembrane domains.; EC=3.4.21.105; case not defined or CC -!- SUBCELLULAR LOCATION: Cell membrane; Multi-pass membrane protein. else case CC -!- SUBCELLULAR LOCATION: Cell inner membrane; Multi-pass membrane protein. end case CC -!- SIMILARITY: Belongs to the peptidase S54 family. XX DR Pfam; PF01694; Rhomboid; 1; trigger=no DR NCBIfam; TIGR04239; rhombo_GlpG; 1; trigger=no DR General; Transmembrane; -; 6; trigger=yes XX KW Cell membrane KW Hydrolase case defined and KW Cell inner membrane end case KW Membrane KW Protease KW Serine protease KW Transmembrane KW Transmembrane helix XX GO GO:0004252; F:serine-type endopeptidase activity GO GO:0006508; P:proteolysis GO GO:0005886; C:plasma membrane XX FT From: GLPG_ECOLI (P09391) FT ACT_SITE 201 FT /note="Nucleophile" FT Condition: S FT ACT_SITE 254 FT Condition: H XX Size: 260-300; Related: None; Template: P09391; Scope: Bacteria; Enterobacterales Fusion: Nter: None Cter: None Duplicate: None Plasmid: None Comments: Active sites are not conserved in CROS8, suggesting that it has no peptidase activity. XX # Revision 1.19 2023/06/01 //