AC   MF_01603;
DC   Protein; auto
TR   HAMAP; MF_01603; -; 1; level=0
XX
Names: HldE
XX
ID   HLDE
DE   RecName: Full=Bifunctional protein HldE;
DE   Includes:
DE     RecName: Full=D-beta-D-heptose 7-phosphate kinase;
DE              EC=2.7.1.167;
DE     AltName: Full=D-beta-D-heptose 7-phosphotransferase;
DE     AltName: Full=D-glycero-beta-D-manno-heptose-7-phosphate kinase;
DE   Includes:
DE     RecName: Full=D-beta-D-heptose 1-phosphate adenylyltransferase;
DE              EC=2.7.7.70;
DE     AltName: Full=D-glycero-beta-D-manno-heptose 1-phosphate adenylyltransferase;
GN   Name=hldE;
XX
CC   -!- FUNCTION: Catalyzes the phosphorylation of D-glycero-D-manno-heptose 7-
CC       phosphate at the C-1 position to selectively form D-glycero-beta-D-
CC       manno-heptose-1,7-bisphosphate.
CC   -!- FUNCTION: Catalyzes the ADP transfer from ATP to D-glycero-beta-D-
CC       manno-heptose 1-phosphate, yielding ADP-D-glycero-beta-D-manno-heptose.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=ATP + D-glycero-beta-D-manno-heptose 7-phosphate = ADP + D-
CC         glycero-beta-D-manno-heptose 1,7-bisphosphate + H(+);
CC         Xref=Rhea:RHEA:27473, ChEBI:CHEBI:15378, ChEBI:CHEBI:30616,
CC         ChEBI:CHEBI:60204, ChEBI:CHEBI:60208, ChEBI:CHEBI:456216;
CC         EC=2.7.1.167;
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=ATP + D-glycero-beta-D-manno-heptose 1-phosphate + H(+) = ADP-
CC         D-glycero-beta-D-manno-heptose + diphosphate; Xref=Rhea:RHEA:27465,
CC         ChEBI:CHEBI:15378, ChEBI:CHEBI:30616, ChEBI:CHEBI:33019,
CC         ChEBI:CHEBI:59967, ChEBI:CHEBI:61593; EC=2.7.7.70;
CC   -!- PATHWAY: Nucleotide-sugar biosynthesis; ADP-L-glycero-beta-D-manno-
CC       heptose biosynthesis; ADP-L-glycero-beta-D-manno-heptose from D-
CC       glycero-beta-D-manno-heptose 7-phosphate: step 1/4.
CC   -!- PATHWAY: Nucleotide-sugar biosynthesis; ADP-L-glycero-beta-D-manno-
CC       heptose biosynthesis; ADP-L-glycero-beta-D-manno-heptose from D-
CC       glycero-beta-D-manno-heptose 7-phosphate: step 3/4.
CC   -!- SUBUNIT: Homodimer.
CC   -!- SIMILARITY: In the N-terminal section; belongs to the carbohydrate
CC       kinase PfkB family.
CC   -!- SIMILARITY: In the C-terminal section; belongs to the
CC       cytidylyltransferase family.
XX
DR   Pfam; PF01467; CTP_transf_2; 1; trigger=no
DR   Pfam; PF00294; PfkB; 1; trigger=no
DR   NCBIfam; TIGR00125; Cyt_tran_rel; 1; trigger=no
DR   NCBIfam; TIGR02198; RfaE_dom_I; 1; trigger=no
DR   NCBIfam; TIGR02199; RfaE_dom_II; 1; trigger=no
DR   PROSITE; PS00583; PFKB_KINASES_1; 1; trigger=no
DR   PROSITE; PS00584; PFKB_KINASES_2; 1; trigger=no
XX
case <FT:5>
KW   Acetylation
end case
KW   ATP-binding
KW   Carbohydrate metabolism
KW   Kinase
KW   Multifunctional enzyme
KW   Nucleotide-binding
KW   Nucleotidyltransferase
KW   Transferase
XX
GO   GO:0005524; F:ATP binding
GO   GO:0033785; F:heptose 7-phosphate kinase activity
GO   GO:0033786; F:heptose-1-phosphate adenylyltransferase activity
GO   GO:0005975; P:carbohydrate metabolic process
XX
FT   From: HLDE_ECOLI (P76658)
FT   BINDING         195..198
FT                   /ligand="ATP"
FT                   /ligand_id="ChEBI:CHEBI:30616"
FT   Condition: N-x-x-E
FT   REGION          Nter..318
FT                   /note="Ribokinase"
FT   REGION          344..Cter
FT                   /note="Cytidylyltransferase"
FT   ACT_SITE        264
FT   Condition: D
case <OC:Escherichia> or <OC:Shigella>
FT   MOD_RES         179
FT                   /note="N6-acetyllysine"
FT   Condition: K
end case
XX
Size: 458-496;
Related: None;
Template: P76658;
Scope:
 Bacteria
Fusion:
 Nter: None
 Cter: None
Duplicate: None
Plasmid: None
Comments: None
XX
# Revision 1.27 2023/06/01
//