AC   MF_01609;
DC   Protein; auto
TR   HAMAP; MF_01609; -; 1; level=0
XX
Names: Glu_cys_ligase_2
XX
ID   GCS2
case <OC:Archaea>
DE   RecName: Full=Glutamate--cysteine ligase;
DE            EC=6.3.2.2;
DE   AltName: Full=Gamma-glutamylcysteine synthetase;
DE            Short=Gamma-GCS;
DE            Short=GCS;
GN   Name=gshA;
else
DE   RecName: Full=Putative glutamate--cysteine ligase 2;
DE            EC=6.3.2.2;
DE   AltName: Full=Gamma-glutamylcysteine synthetase 2;
DE            Short=Gamma-GCS 2;
DE            Short=GCS 2;
end case
XX
case <OC:Archaea>
CC   -!- FUNCTION: Catalyzes the synthesis of gamma-glutamylcysteine (gamma-GC),
CC       the main low-molecular-weight thiol compound instead of glutathione in
CC       halophilic archaea.
else
CC   -!- FUNCTION: ATP-dependent carboxylate-amine ligase which exhibits weak
CC       glutamate--cysteine ligase activity.
end case
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=ATP + L-cysteine + L-glutamate = ADP + gamma-L-glutamyl-L-
CC         cysteine + H(+) + phosphate; Xref=Rhea:RHEA:13285, ChEBI:CHEBI:15378,
CC         ChEBI:CHEBI:29985, ChEBI:CHEBI:30616, ChEBI:CHEBI:35235,
CC         ChEBI:CHEBI:43474, ChEBI:CHEBI:58173, ChEBI:CHEBI:456216; EC=6.3.2.2;
case <OC:Enterobacterales>
CC   -!- SUBUNIT: Homodimer.
end case
CC   -!- SIMILARITY: Belongs to the glutamate--cysteine ligase type 2 family.
CC       YbdK subfamily.
XX
DR   Pfam; PF04107; GCS2; 1; trigger=no
DR   NCBIfam; TIGR02050; GshA_cyan_rel; 1; trigger=no
XX
KW   Ligase
KW   ATP-binding
KW   Nucleotide-binding
XX
case <OC:Archaea>
GO   GO:0004357; F:glutamate-cysteine ligase activity
else
GO   GO:0016879; F:ligase activity, forming carbon-nitrogen bonds
end case
XX
FT   None
XX
Size: 320-426;
Related: None;
Template: D4GZN2; P77213;
Scope:
 Bacteria
 Archaea
Fusion:
 Nter: None
 Cter: <Unknown>; <Peptidase M20>
Duplicate: in PAEAT, ARTS2, COREF, FRAAA, LEGPA, LEGPL, MYCSJ, MYCSK, MYCVP,
 NOCFA, NOCSJ, RHOJR, RUBXD, SACEN, STRAW
Plasmid: None
Comments: None
XX
# Revision 1.26 2023/06/01
//