AC   MF_01610;
DC   Protein; auto
TR   HAMAP; MF_01610; -; 1; level=0
XX
Names: MfnA_decarbox
XX
ID   MFNA
case <OC:Methanobacteria> or <OC:Methanococci> or <OC:Methanomicrobia> or <OC:Methanopyri>
DE   RecName: Full=Probable L-tyrosine/L-aspartate decarboxylase;
DE            Short=TDC/ADC;
DE            EC=4.1.1.25;
DE            EC=4.1.1.11;
else
DE   RecName: Full=Probable L-aspartate decarboxylase;
DE            Short=ADC;
DE            EC=4.1.1.11;
end case
GN   Name=mfnA;
XX
case <OC:Methanobacteria> or <OC:Methanococci> or <OC:Methanomicrobia> or <OC:Methanopyri>
CC   -!- FUNCTION: Catalyzes the decarboxylation of L-tyrosine to produce
CC       tyramine for methanofuran biosynthesis. Can also catalyze the
CC       decarboxylation of L-aspartate to produce beta-alanine for coenzyme A
CC       (CoA) biosynthesis.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=H(+) + L-tyrosine = CO2 + tyramine; Xref=Rhea:RHEA:14345,
CC         ChEBI:CHEBI:15378, ChEBI:CHEBI:16526, ChEBI:CHEBI:58315,
CC         ChEBI:CHEBI:327995; EC=4.1.1.25;
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=H(+) + L-aspartate = beta-alanine + CO2; Xref=Rhea:RHEA:19497,
CC         ChEBI:CHEBI:15378, ChEBI:CHEBI:16526, ChEBI:CHEBI:29991,
CC         ChEBI:CHEBI:57966; EC=4.1.1.11;
else
CC   -!- FUNCTION: Catalyzes the decarboxylation of L-aspartate to produce beta-
CC       alanine.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=H(+) + L-aspartate = beta-alanine + CO2; Xref=Rhea:RHEA:19497,
CC         ChEBI:CHEBI:15378, ChEBI:CHEBI:16526, ChEBI:CHEBI:29991,
CC         ChEBI:CHEBI:57966; EC=4.1.1.11;
end case
CC   -!- COFACTOR:
CC       Name=pyridoxal 5'-phosphate; Xref=ChEBI:CHEBI:597326;
case <OC:Methanobacteria> or <OC:Methanococci> or <OC:Methanomicrobia> or <OC:Methanopyri>
CC   -!- PATHWAY: Cofactor biosynthesis; methanofuran biosynthesis.
end case
CC   -!- PATHWAY: Cofactor biosynthesis; coenzyme A biosynthesis.
CC   -!- SIMILARITY: Belongs to the group II decarboxylase family. MfnA
CC       subfamily.
XX
DR   Pfam; PF00282; Pyridoxal_deC; 1; trigger=no
DR   PROSITE; PS00392; DDC_GAD_HDC_YDC; 1; trigger=no
DR   NCBIfam; TIGR03812; tyr_de_CO2_Arch; 1; trigger=no
XX
KW   Decarboxylase
KW   Lyase
KW   Pyridoxal phosphate
XX
GO   GO:0030170; F:pyridoxal phosphate binding
GO   GO:0004068; F:aspartate 1-decarboxylase activity
GO   GO:0015937; P:coenzyme A biosynthetic process
case <OC:Methanobacteria> or <OC:Methanococci> or <OC:Methanomicrobia> or <OC:Methanopyri>
GO   GO:0004837; F:tyrosine decarboxylase activity
GO   GO:2001120; P:methanofuran biosynthetic process
end case
XX
FT   From: MFNA_METJA (Q60358)
FT   MOD_RES         245
FT                   /note="N6-(pyridoxal phosphate)lysine"
FT   Condition: K
XX
Size: 325-410;
Related: None;
Template: Q60358; Q5JJ82; O58679;
Scope:
 Archaea
Fusion:
 Nter: None
 Cter: None
Duplicate: None
Plasmid: None
Comments: In methanogens, the essential role of MfnA is to generate tyramine for methanofuran biosynthesis, but
 it can also supply the small amount of beta-alanine needed for coenzyme A production (see PubMed:24891443).
XX
# Revision 1.15 2023/06/01
//