AC   MF_01612;
DC   Protein; auto
TR   HAMAP; MF_01612; -; 1; level=0
XX
Names: FO_synth_sub2
XX
ID   COFH
DE   RecName: Full=5-amino-6-(D-ribitylamino)uracil--L-tyrosine 4-hydroxyphenyl transferase;
DE            EC=2.5.1.147;
DE   AltName: Full=FO synthase subunit 2;
GN   Name=cofH;
XX
CC   -!- FUNCTION: Catalyzes the radical-mediated synthesis of 5-amino-5-(4-
CC       hydroxybenzyl)-6-(D-ribitylimino)-5,6-dihydrouracil from 5-amino-6-(D-
CC       ribitylamino)uracil and L-tyrosine.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=5-amino-6-(D-ribitylamino)uracil + L-tyrosine + S-adenosyl-L-
CC         methionine = 2-iminoacetate + 5'-deoxyadenosine + 5-amino-5-(4-
CC         hydroxybenzyl)-6-(D-ribitylimino)-5,6-dihydrouracil + H(+) + L-
CC         methionine; Xref=Rhea:RHEA:55200, ChEBI:CHEBI:15378,
CC         ChEBI:CHEBI:15934, ChEBI:CHEBI:17319, ChEBI:CHEBI:57844,
CC         ChEBI:CHEBI:58315, ChEBI:CHEBI:59789, ChEBI:CHEBI:77846,
CC         ChEBI:CHEBI:85936; EC=2.5.1.147;
case <FTGroup:1>
CC   -!- COFACTOR:
CC       Name=[4Fe-4S] cluster; Xref=ChEBI:CHEBI:49883;
CC       Note=Binds 1 [4Fe-4S] cluster. The cluster is coordinated with 3
CC       cysteines and an exchangeable S-adenosyl-L-methionine.;
end case
CC   -!- PATHWAY: Cofactor biosynthesis; coenzyme F0 biosynthesis.
CC   -!- SUBUNIT: The FO synthase complex consists of two subunits, CofG and
CC       CofH.
CC   -!- SIMILARITY: Belongs to the radical SAM superfamily. CofH family.
XX
DR   Pfam; PF04055; Radical_SAM; 1; trigger=no
DR   PIRSF; PIRSF004762; CHP00423; 1; trigger=no
DR   NCBIfam; TIGR00423; TIGR00423; 1; trigger=no
XX
case <FTGroup:1>
KW   4Fe-4S
KW   Iron
KW   Iron-sulfur
KW   Metal-binding
KW   S-adenosyl-L-methionine
end case
KW   Transferase
XX
case <FTGroup:1>
GO   GO:0005506; F:iron ion binding
end case
GO   GO:0016765; F:transferase activity, transferring alkyl or aryl (other than methyl) groups
XX
FT   From: COFH_METJA (Q58826)
FT   BINDING         59
FT                   /ligand="[4Fe-4S] cluster"
FT                   /ligand_id="ChEBI:CHEBI:49883"
FT                   /ligand_note="4Fe-4S-S-AdoMet"
FT   Group: 1; Condition: C
FT   BINDING         63
FT                   /ligand="[4Fe-4S] cluster"
FT                   /ligand_id="ChEBI:CHEBI:49883"
FT                   /ligand_note="4Fe-4S-S-AdoMet"
FT   Group: 1; Condition: C
FT   BINDING         66
FT                   /ligand="[4Fe-4S] cluster"
FT                   /ligand_id="ChEBI:CHEBI:49883"
FT                   /ligand_note="4Fe-4S-S-AdoMet"
FT   Group: 1; Condition: C
XX
Size: 338-406;
Related: None;
Template: Q58826;
Scope:
 Bacteria; Cyanobacteriota
 Archaea; Euryarchaeota
Fusion:
 Nter: MF_01611 (cofG)
 Cter: None
Duplicate: in METAC, METMA, METMP
Plasmid: None
Comments: Euryarchaeota, cyanobacteria and actinomycetes are known to produce coenzyme FO.
 Euryarchaeota and actinomycetes use it to synthesize coenzyme F420, whereas cyanobacteria
 use it for FO-dependent DNA photolyases.
 In actinomycetes, the two subunits cofG and cofH are fused, and are called fbiC.
 Possible wrong starts.
XX
# Revision 1.26 2023/06/01
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