AC   MF_01614;
DC   Protein; auto
TR   HAMAP; MF_01614; -; 1; level=0
XX
Names: NamA
XX
ID   NAMA
DE   RecName: Full=NADPH dehydrogenase;
DE            EC=1.6.99.1;
GN   Name=namA;
XX
CC   -!- FUNCTION: Catalyzes the reduction of the double bond of an array of
CC       alpha,beta-unsaturated aldehydes and ketones. It also reduces the nitro
CC       group of nitroester and nitroaromatic compounds. It could have a role
CC       in detoxification processes.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=A + H(+) + NADPH = AH2 + NADP(+); Xref=Rhea:RHEA:13149,
CC         ChEBI:CHEBI:13193, ChEBI:CHEBI:15378, ChEBI:CHEBI:17499,
CC         ChEBI:CHEBI:57783, ChEBI:CHEBI:58349; EC=1.6.99.1;
CC   -!- COFACTOR:
CC       Name=FMN; Xref=ChEBI:CHEBI:58210;
CC   -!- SUBUNIT: Homotetramer.
CC   -!- SIMILARITY: Belongs to the NADH:flavin oxidoreductase/NADH oxidase
CC       family. NamA subfamily.
XX
DR   Pfam; PF00724; Oxidored_FMN; 1; trigger=no
XX
KW   Detoxification
KW   Flavoprotein
KW   FMN
KW   NADP
KW   Oxidoreductase
XX
GO   GO:0003959; F:NADPH dehydrogenase activity
GO   GO:0010181; F:FMN binding
GO   GO:0050661; F:NADP binding
XX
FT   From: NAMA_BACSU (P54550)
FT   BINDING         23..26
FT                   /ligand="FMN"
FT                   /ligand_id="ChEBI:CHEBI:58210"
FT   Condition: [SP]-P-M-C
FT   BINDING         307..308
FT                   /ligand="FMN"
FT                   /ligand_id="ChEBI:CHEBI:58210"
FT   Condition: [AG]-R
FT   BINDING         164..167
FT                   /ligand="substrate"
FT   Condition: H-x-x-H
FT   BINDING         28
FT                   /ligand="substrate"
FT   Condition: Y
FT   BINDING         60
FT                   /ligand="FMN"
FT                   /ligand_id="ChEBI:CHEBI:58210"
FT   Condition: A
FT   BINDING         102
FT                   /ligand="FMN"
FT                   /ligand_id="ChEBI:CHEBI:58210"
FT   Condition: Q
FT   BINDING         215
FT                   /ligand="FMN"
FT                   /ligand_id="ChEBI:CHEBI:58210"
FT   Condition: R
XX
Size: 337-346;
Related: None;
Template: P54550;
Scope:
 Bacteria; Bacillales
 Bacteria; Eubacteriales
Fusion:
 Nter: None
 Cter: None
Duplicate: None
Plasmid: None
Comments: None
XX
# Revision 1.19 2022/11/19
//