AC   MF_01618;
DC   Protein; auto
TR   HAMAP; MF_01618; -; 1; level=0
XX
Names: FadI
XX
ID   FADI
DE   RecName: Full=3-ketoacyl-CoA thiolase;
DE            EC=2.3.1.16;
DE   AltName: Full=ACSs;
DE   AltName: Full=Acetyl-CoA acyltransferase;
DE   AltName: Full=Acyl-CoA ligase;
DE   AltName: Full=Beta-ketothiolase;
DE   AltName: Full=Fatty acid oxidation complex subunit beta;
GN   Name=fadI;
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CC   -!- FUNCTION: Catalyzes the final step of fatty acid oxidation in which
CC       acetyl-CoA is released and the CoA ester of a fatty acid two carbons
CC       shorter is formed.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=acetyl-CoA + an acyl-CoA = a 3-oxoacyl-CoA + CoA;
CC         Xref=Rhea:RHEA:21564, ChEBI:CHEBI:57287, ChEBI:CHEBI:57288,
CC         ChEBI:CHEBI:58342, ChEBI:CHEBI:90726; EC=2.3.1.16;
CC   -!- PATHWAY: Lipid metabolism; fatty acid beta-oxidation.
CC   -!- SUBUNIT: Heterotetramer of two alpha chains (FadJ) and two beta chains
CC       (FadI).
CC   -!- SUBCELLULAR LOCATION: Cytoplasm.
CC   -!- SIMILARITY: Belongs to the thiolase-like superfamily. Thiolase family.
XX
DR   PROSITE; PS00098; THIOLASE_1; 1; trigger=no
DR   PROSITE; PS00737; THIOLASE_2; 1; trigger=no
DR   PROSITE; PS00099; THIOLASE_3; 1; trigger=no
DR   Pfam; PF02803; Thiolase_C; 1; trigger=no
DR   Pfam; PF00108; Thiolase_N; 1; trigger=no
DR   NCBIfam; TIGR01930; AcCoA-C-Actrans; 1; trigger=no
DR   NCBIfam; TIGR02446; FadI; 1; trigger=no
XX
KW   Cytoplasm
KW   Acyltransferase
KW   Fatty acid metabolism
KW   Lipid degradation
KW   Lipid metabolism
KW   Transferase
XX
GO   GO:0003988; F:acetyl-CoA C-acyltransferase activity
GO   GO:0006631; P:fatty acid metabolic process
GO   GO:0016042; P:lipid catabolic process
GO   GO:0005737; C:cytoplasm
XX
FT   From: FADI_ECOLI (P76503)
FT   ACT_SITE        99
FT                   /note="Acyl-thioester intermediate"
FT   Condition: C
FT   ACT_SITE        392
FT                   /note="Proton acceptor"
FT   Condition: H
FT   ACT_SITE        422
FT                   /note="Proton acceptor"
FT   Condition: C
XX
Size: 435-442;
Related: None;
Template: P76503;
Scope:
 Bacteria; Gammaproteobacteria
Fusion:
 Nter: None
 Cter: None
Duplicate: None
Plasmid: None
Comments: None
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# Revision 1.20 2023/06/01
//