AC   MF_01624;
DC   Protein; auto
TR   HAMAP; MF_01624; -; 1; level=0
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Names: Arsenate_reduct
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ID   ARSC
DE   RecName: Full=Arsenate reductase;
DE            EC=1.20.4.4;
GN   Name=arsC;
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CC   -!- FUNCTION: Catalyzes the reduction of arsenate [As(V)] to arsenite
CC       [As(III)].
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=[thioredoxin]-dithiol + arsenate + H(+) = [thioredoxin]-
CC         disulfide + arsenite + H2O; Xref=Rhea:RHEA:43848, Rhea:RHEA-
CC         COMP:10698, Rhea:RHEA-COMP:10700, ChEBI:CHEBI:15377,
CC         ChEBI:CHEBI:15378, ChEBI:CHEBI:29242, ChEBI:CHEBI:29950,
CC         ChEBI:CHEBI:48597, ChEBI:CHEBI:50058; EC=1.20.4.4;
CC   -!- SUBCELLULAR LOCATION: Cytoplasm.
CC   -!- SIMILARITY: Belongs to the low molecular weight phosphotyrosine protein
CC       phosphatase family. Thioredoxin-coupled ArsC subfamily.
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DR   Pfam; PF01451; LMWPc; 1; trigger=no
DR   NCBIfam; TIGR02691; arsC_pI258_fam; 1; trigger=no
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KW   Arsenical resistance
KW   Cytoplasm
case <FT:4> or <FT:5>
KW   Disulfide bond
end case
KW   Oxidoreductase
KW   Redox-active center
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GO   GO:0030612; F:arsenate reductase (thioredoxin) activity
GO   GO:0005737; C:cytoplasm
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FT   From: ARSC_STAAU (P0A006)
FT   ACT_SITE        10
FT                   /note="Nucleophile"
FT   Condition: C
FT   ACT_SITE        82
FT                   /note="Nucleophile"
FT   Condition: C
FT   ACT_SITE        89
FT                   /note="Nucleophile"
FT   Condition: C
FT   DISULFID        10..82
FT                   /note="Redox-active; alternate"
FT   Condition: C-x*-C
FT   DISULFID        82..89
FT                   /note="Redox-active; alternate"
FT   Condition: C-x*-C
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Size: 130-160;
Related: None;
Template: P0A006; P45947;
Scope:
 Bacteria; Bacillota
Fusion:
 Nter: None
 Cter: None
Duplicate: in BACC1, STAEQ, STAHJ, STAS1
Plasmid: in BACC1, STAAN, STAAU, STAS1, STAXY
Comments: None
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# Revision 1.20 2023/06/01
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