AC   MF_01633;
DC   Protein; auto
TR   HAMAP; MF_01633; -; 1; level=0
XX
Names: QueC
XX
ID   QUEC
case <OC:Bacteria>
DE   RecName: Full=7-cyano-7-deazaguanine synthase;
DE            EC=6.3.4.20;
DE   AltName: Full=7-cyano-7-carbaguanine synthase;
DE   AltName: Full=PreQ(0) synthase;
DE   AltName: Full=Queuosine biosynthesis protein QueC;
else case <OC:Archaea>
DE   RecName: Full=7-cyano-7-deazaguanine synthase;
DE            EC=6.3.4.20;
DE   AltName: Full=7-cyano-7-carbaguanine synthase;
DE   AltName: Full=Archaeosine biosynthesis protein QueC;
DE   AltName: Full=PreQ(0) synthase;
end case
GN   Name=queC;
XX
CC   -!- FUNCTION: Catalyzes the ATP-dependent conversion of 7-carboxy-7-
CC       deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0)).
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=7-carboxy-7-deazaguanine + ATP + NH4(+) = 7-cyano-7-
CC         deazaguanine + ADP + H(+) + H2O + phosphate; Xref=Rhea:RHEA:27982,
CC         ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:28938,
CC         ChEBI:CHEBI:30616, ChEBI:CHEBI:43474, ChEBI:CHEBI:45075,
CC         ChEBI:CHEBI:61036, ChEBI:CHEBI:456216; EC=6.3.4.20;
case <FTGroup:1>
CC   -!- COFACTOR:
CC       Name=Zn(2+); Xref=ChEBI:CHEBI:29105;
CC       Note=Binds 1 zinc ion per subunit.;
end case
CC   -!- PATHWAY: Purine metabolism; 7-cyano-7-deazaguanine biosynthesis.
case <OC:Bacillota>
CC   -!- SUBUNIT: Homodimer.
end case
CC   -!- SIMILARITY: Belongs to the QueC family.
XX
DR   Pfam; PF06508; ExsB; 1; trigger=no
DR   NCBIfam; TIGR00364; TIGR00364; 1; trigger=no
DR   PIRSF; PIRSF006293; ExsB; 1; trigger=no
XX
KW   ATP-binding
KW   Ligase
KW   Nucleotide-binding
case <FTGroup:1>
KW   Metal-binding
KW   Zinc
end case
case <OC:Bacteria>
KW   Queuosine biosynthesis
end case
XX
GO   GO:0005524; F:ATP binding
GO   GO:0016879; F:ligase activity, forming carbon-nitrogen bonds
case <FTGroup:1>
GO   GO:0008270; F:zinc ion binding
end case
case <OC:Bacteria>
GO   GO:0008616; P:queuosine biosynthetic process
end case
XX
FT   From: QUEC_BACSU (O31675)
FT   BINDING         10..20
FT                   /ligand="ATP"
FT                   /ligand_id="ChEBI:CHEBI:30616"
FT   BINDING         186
FT                   /ligand="Zn(2+)"
FT                   /ligand_id="ChEBI:CHEBI:29105"
FT   Group: 1; Condition: C
FT   BINDING         195
FT                   /ligand="Zn(2+)"
FT                   /ligand_id="ChEBI:CHEBI:29105"
FT   Group: 1; Condition: C
FT   BINDING         198
FT                   /ligand="Zn(2+)"
FT                   /ligand_id="ChEBI:CHEBI:29105"
FT   Group: 1; Condition: C
FT   BINDING         201
FT                   /ligand="Zn(2+)"
FT                   /ligand_id="ChEBI:CHEBI:29105"
FT   Group: 1; Condition: C
XX
Size: 196-269;
Related: None;
Template: P77756; O31675; Q6D820;
Scope:
 Bacteria
 Archaea
Fusion:
 Nter: <type-2 glutamine amidotransferase domain>
 Cter: None
Duplicate: in COLP3, DESHY, PSEF5, RHILO, RHOP2, SPHAL, SULTO
Plasmid: in HALSA, RHIME, SINFN
Comments: None
XX
# Revision 1.23 2023/06/01
//