AC   MF_01634;
DC   Protein; auto
TR   HAMAP; MF_01634; -; 1; level=0
XX
Names: TgtA_arch
XX
ID   ATGT
DE   RecName: Full=tRNA-guanine(15) transglycosylase;
DE            EC=2.4.2.48;
DE   AltName: Full=7-cyano-7-deazaguanine tRNA-ribosyltransferase;
DE   AltName: Full=Archaeal tRNA-guanine transglycosylase;
GN   Name=tgtA;
XX
CC   -!- FUNCTION: Exchanges the guanine residue with 7-cyano-7-deazaguanine
CC       (preQ0) at position 15 in the dihydrouridine loop (D-loop) of archaeal
CC       tRNAs.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=7-cyano-7-deazaguanine + guanosine(15) in tRNA = 7-cyano-7-
CC         carbaguanosine(15) in tRNA + guanine; Xref=Rhea:RHEA:43164,
CC         Rhea:RHEA-COMP:10371, Rhea:RHEA-COMP:10372, ChEBI:CHEBI:16235,
CC         ChEBI:CHEBI:45075, ChEBI:CHEBI:74269, ChEBI:CHEBI:82850; EC=2.4.2.48;
CC   -!- COFACTOR:
CC       Name=Zn(2+); Xref=ChEBI:CHEBI:29105;
CC       Note=Binds 1 zinc ion per subunit.;
CC   -!- PATHWAY: tRNA modification; archaeosine-tRNA biosynthesis.
CC   -!- SIMILARITY: Belongs to the archaeosine tRNA-ribosyltransferase family.
XX
DR   PROSITE; PS50890; PUA; 1; trigger=yes
DR   Pfam; PF01472; PUA; 1; trigger=no
DR   Pfam; PF01702; TGT; 1; trigger=no
DR   NCBIfam; TIGR00432; Arcsn_tRNA_tgt; 1; trigger=no
DR   NCBIfam; TIGR00449; Tgt_general; 1; trigger=no
DR   NCBIfam; TIGR00451; Unchar_dom_2; 1; trigger=no
XX
KW   Glycosyltransferase
KW   Metal-binding
KW   Transferase
KW   tRNA processing
KW   Zinc
XX
GO   GO:0016763; F:pentosyltransferase activity
GO   GO:0008270; F:zinc ion binding
GO   GO:0006400; P:tRNA modification
XX
FT   From: ATGT_PYRHO (O58843)
FT   ACT_SITE        95
FT                   /note="Nucleophile"
FT   Condition: D
FT   BINDING         279
FT                   /ligand="Zn(2+)"
FT                   /ligand_id="ChEBI:CHEBI:29105"
FT   Condition: C
FT   BINDING         281
FT                   /ligand="Zn(2+)"
FT                   /ligand_id="ChEBI:CHEBI:29105"
FT   Condition: C
FT   BINDING         284
FT                   /ligand="Zn(2+)"
FT                   /ligand_id="ChEBI:CHEBI:29105"
FT   Condition: C
FT   BINDING         130
FT                   /ligand="substrate"
FT   Condition: D
FT   BINDING         196
FT                   /ligand="substrate"
FT   Condition: [GA]
XX
Size: 410-674;
Related: None;
Template: O58843; Q57878;
Scope:
 Archaea
Fusion:
 Nter: None
 Cter: None
Duplicate: None
Plasmid: None
Comments: None
XX
# Revision 1.17 2024/01/31
//