AC   MF_01635;
DC   Protein; auto
c?   <OC:Bacteria>
TR   HAMAP; MF_01635; -; 1; level=0
XX
Names: UbiA
XX
case <OC:Pseudomonadota>
ID   UBIA
DE   RecName: Full=4-hydroxybenzoate octaprenyltransferase;
DE            EC=2.5.1.39;
DE   AltName: Full=4-HB polyprenyltransferase;
GN   Name=ubiA;
else case <OC:Cyanobacteriota>
ID   PLQA
DE   RecName: Full=4-hydroxybenzoate solanesyltransferase;
DE            EC=2.5.1.39;
DE   AltName: Full=4-HB polyprenyltransferase;
GN   Name=plqA;
end case
XX
case <OC:Pseudomonadota>
CC   -!- FUNCTION: Catalyzes the prenylation of para-hydroxybenzoate (PHB) with
CC       an all-trans polyprenyl group. Mediates the second step in the final
CC       reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the
CC       condensation of the polyisoprenoid side chain with PHB, generating the
CC       first membrane-bound Q intermediate 3-octaprenyl-4-hydroxybenzoate.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=4-hydroxybenzoate + all-trans-octaprenyl diphosphate = 4-
CC         hydroxy-3-all-trans-octaprenylbenzoate + diphosphate;
CC         Xref=Rhea:RHEA:27782, ChEBI:CHEBI:1617, ChEBI:CHEBI:17879,
CC         ChEBI:CHEBI:33019, ChEBI:CHEBI:57711; EC=2.5.1.39;
CC   -!- PATHWAY: Cofactor biosynthesis; ubiquinone biosynthesis.
else case <OC:Cyanobacteriota>
CC   -!- FUNCTION: Catalyzes the prenylation of para-hydroxybenzoate (PHB) with
CC       an all-trans polyprenyl group. Mediates the second step in the final
CC       reaction sequence of plastoquinone-9 (PQ-9) biosynthesis, which is the
CC       condensation of the polyisoprenoid side chain with PHB, generating the
CC       first membrane-bound Q intermediate 4-hydroxy-3-solanesylbenzoate.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=4-hydroxybenzoate + all-trans-nonaprenyl diphosphate = 4-
CC         hydroxy-3-all-trans-nonaprenylbenzoate + diphosphate;
CC         Xref=Rhea:RHEA:17709, ChEBI:CHEBI:17879, ChEBI:CHEBI:33019,
CC         ChEBI:CHEBI:58391, ChEBI:CHEBI:84502; EC=2.5.1.39;
end case
CC   -!- COFACTOR:
CC       Name=Mg(2+); Xref=ChEBI:CHEBI:18420;
CC   -!- SUBCELLULAR LOCATION: Cell inner membrane; Multi-pass membrane protein.
CC   -!- SIMILARITY: Belongs to the UbiA prenyltransferase family.
XX
DR   PROSITE; PS00943; UBIA; 1; trigger=no
DR   Pfam; PF01040; UbiA; 1; trigger=no
DR   PRINTS; PR01415; ANKYRIN; 1; trigger=no
DR   NCBIfam; TIGR01474; UbiA_proteo; 1; trigger=no
DR   General; Transmembrane; -; 5-9; trigger=yes
XX
KW   Cell membrane
KW   Cell inner membrane
KW   Magnesium
KW   Membrane
KW   Transferase
KW   Transmembrane
KW   Transmembrane helix
case <OC:Pseudomonadota>
KW   Ubiquinone biosynthesis
end case
XX
case <OC:Pseudomonadota>
GO   GO:0008412; F:4-hydroxybenzoate octaprenyltransferase activity
GO   GO:0006744; P:ubiquinone biosynthetic process
else case <OC:Cyanobacteriota>
GO   GO:0004659; F:prenyltransferase activity
GO   GO:0010236; P:plastoquinone biosynthetic process
end case
GO   GO:0005886; C:plasma membrane
XX
Size: 240-390;
Related: None;
Template: P0AGK1; Q55500;
Scope:
 Bacteria; Cyanobacteriota
 Bacteria; Pseudomonadota
Fusion:
 Nter: None
 Cter: None
Duplicate: None
Plasmid: None
Comments: None
XX
# Revision 1.25 2023/06/01
//