AC   MF_01640;
DC   Protein; auto
TR   HAMAP; MF_01640; -; 1; level=0
XX
Names: E4P_dehydrog
XX
ID   E4PD
DE   RecName: Full=D-erythrose-4-phosphate dehydrogenase;
DE            Short=E4PDH;
DE            EC=1.2.1.72;
GN   Name=epd;
XX
CC   -!- FUNCTION: Catalyzes the NAD-dependent conversion of D-erythrose 4-
CC       phosphate to 4-phosphoerythronate.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=D-erythrose 4-phosphate + H2O + NAD(+) = 4-phospho-D-
CC         erythronate + 2 H(+) + NADH; Xref=Rhea:RHEA:12056, ChEBI:CHEBI:15377,
CC         ChEBI:CHEBI:15378, ChEBI:CHEBI:16897, ChEBI:CHEBI:57540,
CC         ChEBI:CHEBI:57945, ChEBI:CHEBI:58766; EC=1.2.1.72;
CC   -!- PATHWAY: Cofactor biosynthesis; pyridoxine 5'-phosphate biosynthesis;
CC       pyridoxine 5'-phosphate from D-erythrose 4-phosphate: step 1/5.
CC   -!- SUBUNIT: Homotetramer.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm.
CC   -!- SIMILARITY: Belongs to the glyceraldehyde-3-phosphate dehydrogenase
CC       family. Epd subfamily.
XX
DR   PROSITE; PS00071; GAPDH; 1; trigger=no
DR   Pfam; PF02800; Gp_dh_C; 1; trigger=no
DR   Pfam; PF00044; Gp_dh_N; 1; trigger=no
DR   PRINTS; PR00078; G3PDHDRGNASE; 1; trigger=no
DR   NCBIfam; TIGR01532; E4PD_g-proteo; 1; trigger=no
XX
KW   Cytoplasm
KW   NAD
KW   Oxidoreductase
KW   Pyridoxine biosynthesis
XX
GO   GO:0048001; F:erythrose-4-phosphate dehydrogenase activity
GO   GO:0042823; P:pyridoxal phosphate biosynthetic process
GO   GO:0008615; P:pyridoxine biosynthetic process
GO   GO:0005737; C:cytoplasm
XX
FT   From: E4PD_ECOLI (P0A9B6)
FT   BINDING         12..13
FT                   /ligand="NAD(+)"
FT                   /ligand_id="ChEBI:CHEBI:57540"
FT   Condition: R-[IV]
FT   BINDING         154..156
FT                   /ligand="substrate"
FT   Condition: S-C-T
FT   BINDING         213..214
FT                   /ligand="substrate"
FT   Condition: T-[KR]
FT   ACT_SITE        155
FT                   /note="Nucleophile"
FT   Condition: C
FT   BINDING         81
FT                   /ligand="NAD(+)"
FT                   /ligand_id="ChEBI:CHEBI:57540"
FT   Optional; Condition: R
FT   BINDING         200
FT                   /ligand="substrate"
FT   Optional; Condition: R
FT   BINDING         236
FT                   /ligand="substrate"
FT   Optional; Condition: R
FT   BINDING         318
FT                   /ligand="NAD(+)"
FT                   /ligand_id="ChEBI:CHEBI:57540"
FT   Optional; Condition: N
FT   SITE            182
FT                   /note="Activates thiol group during catalysis"
FT   Condition: H
XX
Size: 336-371;
Related: None;
Template: P0A9B6;
Scope:
 Bacteria; Pseudomonadota
Fusion:
 Nter: None
 Cter: None
Duplicate: None
Plasmid: None
Comments: None
XX
# Revision 1.24 2023/06/01
//