AC MF_01643; DC Protein; auto TR HAMAP; MF_01643; -; 1; level=0 XX Names: PurT XX ID PURT DE RecName: Full=Formate-dependent phosphoribosylglycinamide formyltransferase; DE EC=6.3.1.21; DE AltName: Full=Formate-dependent GAR transformylase; DE AltName: Full=Non-folate glycinamide ribonucleotide transformylase; DE AltName: Full=Phosphoribosylglycinamide formyltransferase 2; DE AltName: Full=5'-phosphoribosylglycinamide transformylase 2; DE AltName: Full=GAR transformylase 2; DE Short=GART 2; GN Name=purT; XX CC -!- FUNCTION: Involved in the de novo purine biosynthesis. Catalyzes the CC transfer of formate to 5-phospho-ribosyl-glycinamide (GAR), producing CC 5-phospho-ribosyl-N-formylglycinamide (FGAR). Formate is provided by CC PurU via hydrolysis of 10-formyl-tetrahydrofolate. CC -!- CATALYTIC ACTIVITY: CC Reaction=ATP + formate + N(1)-(5-phospho-beta-D-ribosyl)glycinamide = CC ADP + H(+) + N(2)-formyl-N(1)-(5-phospho-beta-D-ribosyl)glycinamide + CC phosphate; Xref=Rhea:RHEA:24829, ChEBI:CHEBI:15378, CC ChEBI:CHEBI:15740, ChEBI:CHEBI:30616, ChEBI:CHEBI:43474, CC ChEBI:CHEBI:143788, ChEBI:CHEBI:147286, ChEBI:CHEBI:456216; CC EC=6.3.1.21; CC PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:24830; CC -!- PATHWAY: Purine metabolism; IMP biosynthesis via de novo pathway; N(2)- CC formyl-N(1)-(5-phospho-D-ribosyl)glycinamide from N(1)-(5-phospho-D- CC ribosyl)glycinamide (formate route): step 1/1. CC -!- SUBUNIT: Homodimer. CC -!- SIMILARITY: Belongs to the PurK/PurT family. XX DR PROSITE; PS50975; ATP_GRASP; 1; trigger=no DR Pfam; PF02222; ATP-grasp; 1; trigger=no DR NCBIfam; TIGR01142; PurT; 1; trigger=no XX KW ATP-binding KW Ligase KW Metal-binding KW Magnesium KW Nucleotide-binding KW Purine biosynthesis XX GO GO:0000166; F:nucleotide binding GO GO:0005524; F:ATP binding GO GO:0043815; F:phosphoribosylglycinamide formyltransferase 2 activity GO GO:0006189; P:'de novo' IMP biosynthetic process XX FT From: PURT_ECOLI (P33221) case FT DOMAIN 119..308 FT /note="ATP-grasp" end case FT BINDING 160..165 FT /ligand="ATP" FT /ligand_id="ChEBI:CHEBI:30616" FT Condition: S-S-G-x-G-Q FT BINDING 195..198 FT /ligand="ATP" FT /ligand_id="ChEBI:CHEBI:30616" FT Condition: E-x-x-[VIAL] FT BINDING 22..23 FT /ligand="N(1)-(5-phospho-beta-D-ribosyl)glycinamide" FT /ligand_id="ChEBI:CHEBI:143788" FT Condition: E-L FT BINDING 362..363 FT /ligand="N(1)-(5-phospho-beta-D-ribosyl)glycinamide" FT /ligand_id="ChEBI:CHEBI:143788" FT Condition: R-R FT BINDING 267 FT /ligand="Mg(2+)" FT /ligand_id="ChEBI:CHEBI:18420" FT Condition: E FT BINDING 279 FT /ligand="Mg(2+)" FT /ligand_id="ChEBI:CHEBI:18420" FT Condition: [ED] FT BINDING 82 FT /ligand="N(1)-(5-phospho-beta-D-ribosyl)glycinamide" FT /ligand_id="ChEBI:CHEBI:143788" FT Condition: E FT BINDING 114 FT /ligand="ATP" FT /ligand_id="ChEBI:CHEBI:30616" FT Condition: R FT BINDING 155 FT /ligand="ATP" FT /ligand_id="ChEBI:CHEBI:30616" FT Condition: K FT BINDING 203 FT /ligand="ATP" FT /ligand_id="ChEBI:CHEBI:30616" FT Condition: E FT BINDING 286 FT /ligand="N(1)-(5-phospho-beta-D-ribosyl)glycinamide" FT /ligand_id="ChEBI:CHEBI:143788" FT Condition: D FT BINDING 355 FT /ligand="N(1)-(5-phospho-beta-D-ribosyl)glycinamide" FT /ligand_id="ChEBI:CHEBI:143788" FT Condition: K XX Size: 379-439; Related: None; Template: P33221; Scope: Bacteria Archaea Fusion: Nter: None Cter: None Duplicate: None Plasmid: None Comments: None XX # Revision 1.27 2023/06/01 //