AC   MF_01647;
DC   Protein; auto
TR   HAMAP; MF_01647; -; 1; level=0
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Names: HcaB
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ID   HCAB
DE   RecName: Full=3-phenylpropionate-dihydrodiol/cinnamic acid-dihydrodiol dehydrogenase;
DE            EC=1.3.1.87;
DE   AltName: Full=2,3-dihydroxy-2,3-dihydrophenylpropionate dehydrogenase;
DE   AltName: Full=3-(cis-5,6-dihydroxycyclohexa-1,3-dien-1-yl)propanoate dehydrogenase;
DE   AltName: Full=CI-dihydrodiol dehydrogenase;
DE   AltName: Full=Cis-3-(2-carboxyethenyl)-3,5-cyclohexadiene-1,2-diol dehydrogenase;
DE   AltName: Full=Cis-3-(2-carboxyethyl)-3,5-cyclohexadiene-1,2-diol dehydrogenase;
DE   AltName: Full=PP-dihydrodiol dehydrogenase;
GN   Name=hcaB;
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CC   -!- FUNCTION: Converts 3-phenylpropionate-dihydrodiol (PP-dihydrodiol) and
CC       cinnamic acid-dihydrodiol (CI-dihydrodiol) into 3-(2,3-
CC       dihydroxylphenyl)propanoic acid (DHPP) and 2,3-dihydroxicinnamic acid
CC       (DHCI), respectively.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=3-(cis-5,6-dihydroxycyclohexa-1,3-dien-1-yl)propanoate +
CC         NAD(+) = 3-(2,3-dihydroxyphenyl)propanoate + H(+) + NADH;
CC         Xref=Rhea:RHEA:25062, ChEBI:CHEBI:15378, ChEBI:CHEBI:46951,
CC         ChEBI:CHEBI:57540, ChEBI:CHEBI:57945, ChEBI:CHEBI:60087; EC=1.3.1.87;
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=(2E)-3-(cis-5,6-dihydroxycyclohexa-1,3-dien-1-yl)prop-2-enoate
CC         + NAD(+) = (2E)-3-(2,3-dihydroxyphenyl)prop-2-enoate + H(+) + NADH;
CC         Xref=Rhea:RHEA:25066, ChEBI:CHEBI:15378, ChEBI:CHEBI:57540,
CC         ChEBI:CHEBI:57945, ChEBI:CHEBI:58642, ChEBI:CHEBI:61451; EC=1.3.1.87;
CC   -!- PATHWAY: Aromatic compound metabolism; 3-phenylpropanoate degradation.
CC   -!- SIMILARITY: Belongs to the short-chain dehydrogenases/reductases (SDR)
CC       family.
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DR   PROSITE; PS00061; ADH_SHORT; 1; trigger=no
DR   Pfam; PF00106; adh_short; 1; trigger=no
DR   PRINTS; PR00081; GDHRDH; 1; trigger=no
DR   PRINTS; PR00080; SDRFAMILY; 1; trigger=no
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KW   Aromatic hydrocarbons catabolism
KW   NAD
KW   Oxidoreductase
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GO   GO:0016491; F:oxidoreductase activity
GO   GO:0018498; F:2,3-dihydroxy-2,3-dihydro-phenylpropionate dehydrogenase activity
GO   GO:0019439; P:aromatic compound catabolic process
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FT   From: HCAB_ECOLI (P0CI31)
FT   BINDING         10..34
FT                   /ligand="NAD(+)"
FT                   /ligand_id="ChEBI:CHEBI:57540"
FT   ACT_SITE        156
FT                   /note="Proton acceptor"
FT   Condition: Y
FT   BINDING         143
FT                   /ligand="substrate"
FT   Condition: S
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Size: 270-280;
Related: None;
Template: P0CI31;
Scope:
 Bacteria; Enterobacterales
Fusion:
 Nter: None
 Cter: None
Duplicate: None
Plasmid: None
Comments: None
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# Revision 1.20 2022/11/19
//