AC MF_01648; DC Protein; auto TR HAMAP; MF_01648; -; 1; level=0 XX Names: HcaE XX ID HCAE DE RecName: Full=3-phenylpropionate/cinnamic acid dioxygenase subunit alpha; DE EC=1.14.12.19; GN Name=hcaE; XX CC -!- FUNCTION: Part of the multicomponent 3-phenylpropionate dioxygenase. CC Converts 3-phenylpropionic acid (PP) and cinnamic acid (CI) into 3- CC phenylpropionate-dihydrodiol (PP-dihydrodiol) and cinnamic acid- CC dihydrodiol (CI-dihydrodiol), respectively. CC -!- CATALYTIC ACTIVITY: CC Reaction=3-phenylpropanoate + H(+) + NADH + O2 = 3-(cis-5,6- CC dihydroxycyclohexa-1,3-dien-1-yl)propanoate + NAD(+); CC Xref=Rhea:RHEA:20357, ChEBI:CHEBI:15378, ChEBI:CHEBI:15379, CC ChEBI:CHEBI:51057, ChEBI:CHEBI:57540, ChEBI:CHEBI:57945, CC ChEBI:CHEBI:60087; EC=1.14.12.19; CC -!- CATALYTIC ACTIVITY: CC Reaction=(E)-cinnamate + H(+) + NADH + O2 = (2E)-3-(cis-5,6- CC dihydroxycyclohexa-1,3-dien-1-yl)prop-2-enoate + NAD(+); CC Xref=Rhea:RHEA:25058, ChEBI:CHEBI:15378, ChEBI:CHEBI:15379, CC ChEBI:CHEBI:15669, ChEBI:CHEBI:57540, ChEBI:CHEBI:57945, CC ChEBI:CHEBI:61451; EC=1.14.12.19; CC -!- COFACTOR: CC Name=Fe cation; Xref=ChEBI:CHEBI:24875; CC Note=Binds 1 Fe cation.; CC -!- COFACTOR: CC Name=[2Fe-2S] cluster; Xref=ChEBI:CHEBI:190135; CC Note=Binds 1 [2Fe-2S] cluster per subunit. CC -!- PATHWAY: Aromatic compound metabolism; 3-phenylpropanoate degradation. CC -!- SUBUNIT: This dioxygenase system consists of four proteins: the two CC subunits of the hydroxylase component (HcaE and HcaF), a ferredoxin CC (HcaC) and a ferredoxin reductase (HcaD). CC -!- SIMILARITY: Belongs to the bacterial ring-hydroxylating dioxygenase CC alpha subunit family. XX DR PROSITE; PS51296; RIESKE; 1; trigger=yes DR PROSITE; PS00570; RING_HYDROXYL_ALPHA; 1; trigger=no DR Pfam; PF00355; Rieske; 1; trigger=no DR Pfam; PF00848; Ring_hydroxyl_A; 1; trigger=no DR PRINTS; PR00090; RNGDIOXGNASE; 1; trigger=no XX KW 2Fe-2S KW Aromatic hydrocarbons catabolism KW Dioxygenase KW Iron KW Iron-sulfur KW Metal-binding KW NAD KW Oxidoreductase XX GO GO:0005506; F:iron ion binding GO GO:0008695; F:3-phenylpropionate dioxygenase activity GO GO:0019439; P:aromatic compound catabolic process XX FT From: HCAE_ECOLI (P0ABR5) FT BINDING 85 FT /ligand="[2Fe-2S] cluster" FT /ligand_id="ChEBI:CHEBI:190135" FT Condition: C FT BINDING 87 FT /ligand="[2Fe-2S] cluster" FT /ligand_id="ChEBI:CHEBI:190135" FT Condition: H FT BINDING 105 FT /ligand="[2Fe-2S] cluster" FT /ligand_id="ChEBI:CHEBI:190135" FT Condition: C FT BINDING 108 FT /ligand="[2Fe-2S] cluster" FT /ligand_id="ChEBI:CHEBI:190135" FT Condition: H FT BINDING 213 FT /ligand="Fe cation" FT /ligand_id="ChEBI:CHEBI:24875" FT Condition: H FT BINDING 218 FT /ligand="Fe cation" FT /ligand_id="ChEBI:CHEBI:24875" FT Condition: H XX Size: 453-453; Related: None; Template: P0ABR5; Scope: Bacteria; Enterobacterales Fusion: Nter: None Cter: None Duplicate: None Plasmid: None Comments: None XX # Revision 1.24 2022/11/19 //