AC   MF_01652;
DC   Protein; auto
TR   HAMAP; MF_01652; -; 1; level=0
XX
Names: MhpA
XX
ID   MHPA
DE   RecName: Full=3-(3-hydroxy-phenyl)propionate/3-hydroxycinnamic acid hydroxylase;
DE            Short=3-HCI hydroxylase;
DE            Short=3-HPP hydroxylase;
DE            EC=1.14.13.127;
GN   Name=mhpA;
XX
CC   -!- FUNCTION: Catalyzes the insertion of one atom of molecular oxygen into
CC       position 2 of the phenyl ring of 3-(3-hydroxyphenyl)propionate (3-HPP)
CC       and hydroxycinnamic acid (3HCI).
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=3-(3-hydroxyphenyl)propanoate + H(+) + NADH + O2 = 3-(2,3-
CC         dihydroxyphenyl)propanoate + H2O + NAD(+); Xref=Rhea:RHEA:24785,
CC         ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:15379,
CC         ChEBI:CHEBI:46951, ChEBI:CHEBI:57277, ChEBI:CHEBI:57540,
CC         ChEBI:CHEBI:57945; EC=1.14.13.127;
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=(2E)-3-(3-hydroxyphenyl)prop-2-enoate + H(+) + NADH + O2 =
CC         (2E)-3-(2,3-dihydroxyphenyl)prop-2-enoate + H2O + NAD(+);
CC         Xref=Rhea:RHEA:27846, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378,
CC         ChEBI:CHEBI:15379, ChEBI:CHEBI:47928, ChEBI:CHEBI:57540,
CC         ChEBI:CHEBI:57945, ChEBI:CHEBI:58642; EC=1.14.13.127;
CC   -!- COFACTOR:
CC       Name=FAD; Xref=ChEBI:CHEBI:57692;
CC   -!- PATHWAY: Aromatic compound metabolism; 3-phenylpropanoate degradation.
CC   -!- SIMILARITY: Belongs to the PheA/TfdB FAD monooxygenase family.
XX
DR   Pfam; PF01494; FAD_binding_3; 1; trigger=no
DR   PRINTS; PR00420; RNGMNOXGNASE; 1; trigger=no
DR   PRINTS; PR00368; FADPNR; 1; trigger=no
XX
KW   Aromatic hydrocarbons catabolism
KW   FAD
KW   Flavoprotein
KW   NAD
KW   Oxidoreductase
XX
GO   GO:0008688; F:3-(3-hydroxyphenyl)propionate hydroxylase activity
GO   GO:0019622; P:3-(3-hydroxy)phenylpropionate catabolic process
XX
FT   From: MHPA_ECOLI (P77397)
FT   BINDING         17..46
FT                   /ligand="FAD"
FT                   /ligand_id="ChEBI:CHEBI:57692"
FT   BINDING         285..295
FT                   /ligand="FAD"
FT                   /ligand_id="ChEBI:CHEBI:57692"
XX
Size: 439-622;
Related: None;
Template: P77397;
Scope:
 Bacteria; Mycobacteriales
 Bacteria; Pseudomonadota
Fusion:
 Nter: None
 Cter: None
Duplicate: in BURVG
Plasmid: None
Comments: None
XX
# Revision 1.25 2023/02/17
//