AC   MF_01653;
DC   Protein; auto
TR   HAMAP; MF_01653; -; 1; level=0
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Names: MhpB
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ID   MHPB
DE   RecName: Full=2,3-dihydroxyphenylpropionate/2,3-dihydroxicinnamic acid 1,2-dioxygenase;
DE            EC=1.13.11.16;
DE   AltName: Full=3-carboxyethylcatechol 2,3-dioxygenase;
GN   Name=mhpB;
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CC   -!- FUNCTION: Catalyzes the non-heme iron(II)-dependent oxidative cleavage
CC       of 2,3-dihydroxyphenylpropionic acid and 2,3-dihydroxicinnamic acid
CC       into 2-hydroxy-6-ketononadienedioate and 2-hydroxy-6-
CC       ketononatrienedioate, respectively.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=3-(2,3-dihydroxyphenyl)propanoate + O2 = (2Z,4E)-2-hydroxy-6-
CC         oxonona-2,4-dienedioate + H(+); Xref=Rhea:RHEA:23840,
CC         ChEBI:CHEBI:15378, ChEBI:CHEBI:15379, ChEBI:CHEBI:46951,
CC         ChEBI:CHEBI:66887; EC=1.13.11.16;
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=(2E)-3-(2,3-dihydroxyphenyl)prop-2-enoate + O2 = (2Z,4E,7E)-2-
CC         hydroxy-6-oxonona-2,4,7-trienedioate + H(+); Xref=Rhea:RHEA:25054,
CC         ChEBI:CHEBI:15378, ChEBI:CHEBI:15379, ChEBI:CHEBI:58642,
CC         ChEBI:CHEBI:66888; EC=1.13.11.16;
CC   -!- COFACTOR:
CC       Name=Fe(2+); Xref=ChEBI:CHEBI:29033;
CC   -!- PATHWAY: Aromatic compound metabolism; 3-phenylpropanoate degradation.
CC   -!- SUBUNIT: Homotetramer.
CC   -!- SIMILARITY: Belongs to the LigB/MhpB extradiol dioxygenase family.
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DR   Pfam; PF02900; LigB; 1; trigger=no
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KW   Aromatic hydrocarbons catabolism
KW   Dioxygenase
KW   Iron
KW   Oxidoreductase
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GO   GO:0005506; F:iron ion binding
GO   GO:0047070; F:3-carboxyethylcatechol 2,3-dioxygenase activity
GO   GO:0019439; P:aromatic compound catabolic process
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FT   From: MHPB_ECOLI (P0ABR9)
FT   ACT_SITE        115
FT                   /note="Proton donor"
FT   Condition: H
FT   ACT_SITE        179
FT                   /note="Proton acceptor"
FT   Condition: H
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Size: 311-331;
Related: None;
Template: P0ABR9;
Scope:
 Bacteria; Actinomycetota
 Bacteria; Pseudomonadota
Fusion:
 Nter: None
 Cter: None
Duplicate: in DECAR, PSEPU
Plasmid: in PSEPU
Comments: None
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# Revision 1.19 2023/01/26
//