AC MF_01654; DC Protein; auto TR HAMAP; MF_01654; -; 1; level=0 XX Names: MhpC XX ID MHPC DE RecName: Full=2-hydroxy-6-oxononadienedioate/2-hydroxy-6-oxononatrienedioate hydrolase; DE EC=3.7.1.14; DE AltName: Full=2-hydroxy-6-ketonona-2,4-diene-1,9-dioic acid 5,6-hydrolase; DE AltName: Full=2-hydroxy-6-oxonona-2,4,7-triene-1,9-dioic acid 5,6-hydrolase; DE AltName: Full=2-hydroxy-6-oxonona-2,4-diene-1,9-dioic acid 5,6-hydrolase; GN Name=mhpC; XX CC -!- FUNCTION: Catalyzes the cleavage of the C5-C6 bond of 2-hydroxy-6- CC oxononadienedioate and 2-hydroxy-6-oxononatrienedioate, a dienol ring CC fission product of the bacterial meta-cleavage pathway for degradation CC of phenylpropionic acid. CC -!- CATALYTIC ACTIVITY: CC Reaction=(2Z,4E)-2-hydroxy-6-oxonona-2,4-dienedioate + H2O = (2Z)-2- CC hydroxypenta-2,4-dienoate + H(+) + succinate; Xref=Rhea:RHEA:34187, CC ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:30031, CC ChEBI:CHEBI:66887, ChEBI:CHEBI:67152; EC=3.7.1.14; CC -!- CATALYTIC ACTIVITY: CC Reaction=(2Z,4E,7E)-2-hydroxy-6-oxonona-2,4,7-trienedioate + H2O = CC (2Z)-2-hydroxypenta-2,4-dienoate + fumarate + H(+); CC Xref=Rhea:RHEA:34191, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, CC ChEBI:CHEBI:29806, ChEBI:CHEBI:66888, ChEBI:CHEBI:67152; EC=3.7.1.14; CC -!- PATHWAY: Aromatic compound metabolism; 3-phenylpropanoate degradation. CC -!- SUBUNIT: Homodimer. CC -!- SIMILARITY: Belongs to the AB hydrolase superfamily. MhpC family. XX DR Pfam; PF00561; Abhydrolase_1; 1; trigger=yes DR PRINTS; PR00111; ABHYDROLASE; 1; trigger=no DR PRINTS; PR00412; EPOXHYDRLASE; 1; trigger=no XX KW Aromatic hydrocarbons catabolism KW Hydrolase XX GO GO:0018771; F:2-hydroxy-6-oxonona-2,4-dienedioate hydrolase activity GO GO:0019439; P:aromatic compound catabolic process XX FT From: MHPC_ECOLI (P77044) FT ACT_SITE 267 FT /note="Proton acceptor" FT Condition: H FT SITE 114 FT /note="Transition state stabilizer" FT Condition: S FT SITE 192 FT /note="Catalytic role in ketonization of the dienol FT substrate (substrate destabilization)" FT Condition: R XX Size: 285-296; Related: None; Template: P77044; Scope: Bacteria; Pseudomonadota Fusion: Nter: None Cter: None Duplicate: in DECAR, PSEPU Plasmid: None Comments: BURCE and COMTE are tagged as atypical due to their sequence similarity to BphD. XX # Revision 1.21 2023/01/26 //