AC   MF_01657;
DC   Protein; auto
TR   HAMAP; MF_01657; -; 1; level=0
XX
Names: Ac_ald_DH_ac
XX
ID   ACDH
DE   RecName: Full=Acetaldehyde dehydrogenase;
DE            EC=1.2.1.10;
DE   AltName: Full=Acetaldehyde dehydrogenase [acetylating];
case <OC:Enterobacterales>
GN   Name=mhpF;
end case
XX
case <OC:Enterobacterales>
CC   -!- FUNCTION: Catalyzes the conversion of acetaldehyde to acetyl-CoA, using
CC       NAD(+) and coenzyme A. Is the final enzyme in the meta-cleavage pathway
CC       for the degradation of aromatic compounds.
end case
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=acetaldehyde + CoA + NAD(+) = acetyl-CoA + H(+) + NADH;
CC         Xref=Rhea:RHEA:23288, ChEBI:CHEBI:15343, ChEBI:CHEBI:15378,
CC         ChEBI:CHEBI:57287, ChEBI:CHEBI:57288, ChEBI:CHEBI:57540,
CC         ChEBI:CHEBI:57945; EC=1.2.1.10;
case <OC:Enterobacterales>
CC   -!- PATHWAY: Aromatic compound metabolism; 3-phenylpropanoate degradation.
CC   -!- SUBUNIT: Interacts with MhpE.
end case
CC   -!- SIMILARITY: Belongs to the acetaldehyde dehydrogenase family.
XX
DR   Pfam; PF09290; AcetDehyd-dimer; 1; trigger=no
DR   Pfam; PF01118; Semialdhyde_dh; 1; trigger=no
DR   NCBIfam; TIGR03215; Ac_ald_DH_ac; 1; trigger=no
DR   PIRSF; PIRSF015689; Actaldh_dh_actl; 1; trigger=no
XX
KW   Aromatic hydrocarbons catabolism
KW   NAD
KW   Oxidoreductase
XX
GO   GO:0008774; F:acetaldehyde dehydrogenase (acetylating) activity
GO   GO:0051287; F:NAD binding
GO   GO:0019439; P:aromatic compound catabolic process
XX
FT   From: ACDH_PSEUF (Q52060)
FT   BINDING         12..15
FT                   /ligand="NAD(+)"
FT                   /ligand_id="ChEBI:CHEBI:57540"
FT   Optional; Condition: [ST]-G-[NDAVS]-[IV]
FT   BINDING         163..171
FT                   /ligand="NAD(+)"
FT                   /ligand_id="ChEBI:CHEBI:57540"
FT   Optional; Condition: [SG]-x-G-[PI]-[GA]-[TS]-x-x-N
FT   ACT_SITE        132
FT                   /note="Acyl-thioester intermediate"
FT   Condition: C
FT   BINDING         290
FT                   /ligand="NAD(+)"
FT                   /ligand_id="ChEBI:CHEBI:57540"
FT   Condition: N
XX
Size: 262-336;
Related: None;
Template: P77580; Q9KWS1; Q79AF6; Q52060; Q53WH9;
Scope:
 Bacteria
Fusion:
 Nter: None
 Cter: None
Duplicate: in AZOSB, AZOVD, BURCJ, PARP8, BURL3, BURVG, PARXL, COMTE, DECAR,
 FRASN, METPP, MYCA9, MYCMM, MYCS2, MYCSJ, MYCSK, MYCSS, MYCUA, MYCVP, NOCFA,
 NOCSJ, NOVAD, PSEP1, PSEFK, PSEPW, CUPNH, CUPMC, RHOE4, RHOOB, RHOJR, SALAI,
 RHIWR
Plasmid: in GEOSE, BURCE, BURVG, MYCSK, MYCSS, NOVAD, POLNA, POLSJ, PSEPU,
 CUPMC, RALN1, RHOOB, RHOJR, SPHAR, RHIWR, THET8
Comments: This protein is present in multiple copies in some organisms, each one
 being located in a cluster involved in the degragation of a different aromatic compound.
XX
# Revision 1.35 2023/11/28
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