AC MF_01659; DC Protein; auto TR HAMAP; MF_01659; -; 1; level=0 XX Names: MenD XX ID MEND case not DE RecName: Full=2-succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexene-1-carboxylate synthase; DE Short=SEPHCHC synthase; DE EC=2.2.1.9; DE AltName: Full=Menaquinone biosynthesis protein MenD; else case DE RecName: Full=2-succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexene-1-carboxylate synthase; DE Short=SEPHCHC synthase; DE EC=2.2.1.9; end case GN Name=menD; XX CC -!- FUNCTION: Catalyzes the thiamine diphosphate-dependent decarboxylation CC of 2-oxoglutarate and the subsequent addition of the resulting succinic CC semialdehyde-thiamine pyrophosphate anion to isochorismate to yield 2- CC succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexene-1-carboxylate (SEPHCHC). CC -!- CATALYTIC ACTIVITY: CC Reaction=2-oxoglutarate + H(+) + isochorismate = 5-enolpyruvoyl-6- CC hydroxy-2-succinyl-cyclohex-3-ene-1-carboxylate + CO2; CC Xref=Rhea:RHEA:25593, ChEBI:CHEBI:15378, ChEBI:CHEBI:16526, CC ChEBI:CHEBI:16810, ChEBI:CHEBI:29780, ChEBI:CHEBI:58818; EC=2.2.1.9; CC -!- COFACTOR: CC Name=Mg(2+); Xref=ChEBI:CHEBI:18420; CC Name=Mn(2+); Xref=ChEBI:CHEBI:29035; CC -!- COFACTOR: CC Name=thiamine diphosphate; Xref=ChEBI:CHEBI:58937; CC Note=Binds 1 thiamine pyrophosphate per subunit.; CC -!- PATHWAY: Quinol/quinone metabolism; 1,4-dihydroxy-2-naphthoate CC biosynthesis; 1,4-dihydroxy-2-naphthoate from chorismate: step 2/7. case not CC -!- PATHWAY: Quinol/quinone metabolism; menaquinone biosynthesis. else case CC -!- PATHWAY: Cofactor biosynthesis; phylloquinone biosynthesis. end case CC -!- SUBUNIT: Homodimer. CC -!- SIMILARITY: Belongs to the TPP enzyme family. MenD subfamily. XX DR Pfam; PF02776; TPP_enzyme_N; 1; trigger=no DR NCBIfam; TIGR00173; MenD; 1; trigger=no XX KW Magnesium KW Manganese case not KW Menaquinone biosynthesis end case KW Metal-binding KW Thiamine pyrophosphate KW Transferase XX GO GO:0070204; F:2-succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexene-1-carboxylic-acid synthase activity GO GO:0000287; F:magnesium ion binding GO GO:0030145; F:manganese ion binding GO GO:0030976; F:thiamine pyrophosphate binding case not GO GO:0009234; P:menaquinone biosynthetic process else case GO GO:0042372; P:phylloquinone biosynthetic process end case XX Size: 497-700; Related: None; Template: P17109; Scope: Bacteria Archaea Fusion: Nter: None Cter: None Duplicate: None Plasmid: None Comments: None XX # Revision 1.19 2023/06/01 //