AC   MF_01660;
DC   Protein; auto
TR   HAMAP; MF_01660; -; 1; level=0
XX
Names: MenH
XX
ID   MENH
case <OC:Enterobacterales>
DE   RecName: Full=2-succinyl-6-hydroxy-2,4-cyclohexadiene-1-carboxylate synthase;
DE            Short=SHCHC synthase;
DE            EC=4.2.99.20;
else
DE   RecName: Full=Putative 2-succinyl-6-hydroxy-2,4-cyclohexadiene-1-carboxylate synthase;
DE            Short=SHCHC synthase;
DE            EC=4.2.99.20;
end case
GN   Name=menH;
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CC   -!- FUNCTION: Catalyzes a proton abstraction reaction that results in 2,5-
CC       elimination of pyruvate from 2-succinyl-5-enolpyruvyl-6-hydroxy-3-
CC       cyclohexene-1-carboxylate (SEPHCHC) and the formation of 2-succinyl-6-
CC       hydroxy-2,4-cyclohexadiene-1-carboxylate (SHCHC).
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=5-enolpyruvoyl-6-hydroxy-2-succinyl-cyclohex-3-ene-1-
CC         carboxylate = (1R,6R)-6-hydroxy-2-succinyl-cyclohexa-2,4-diene-1-
CC         carboxylate + pyruvate; Xref=Rhea:RHEA:25597, ChEBI:CHEBI:15361,
CC         ChEBI:CHEBI:58689, ChEBI:CHEBI:58818; EC=4.2.99.20;
CC   -!- PATHWAY: Quinol/quinone metabolism; 1,4-dihydroxy-2-naphthoate
CC       biosynthesis; 1,4-dihydroxy-2-naphthoate from chorismate: step 3/7.
case not <OC:Cyanobacteriota>
CC   -!- PATHWAY: Quinol/quinone metabolism; menaquinone biosynthesis.
else case <OC:Cyanobacteriota>
CC   -!- PATHWAY: Cofactor biosynthesis; phylloquinone biosynthesis.
end case
CC   -!- SUBUNIT: Monomer.
CC   -!- SIMILARITY: Belongs to the AB hydrolase superfamily. MenH family.
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DR   Pfam; PF00561; Abhydrolase_1; 1; trigger=no
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KW   Lyase
case not <OC:Cyanobacteriota>
KW   Menaquinone biosynthesis
end case
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GO   GO:0070205; F:2-succinyl-6-hydroxy-2,4-cyclohexadiene-1-carboxylate synthase activity
case not <OC:Cyanobacteriota>
GO   GO:0009234; P:menaquinone biosynthetic process
else case <OC:Cyanobacteriota>
GO   GO:0042372; P:phylloquinone biosynthetic process
end case
XX
Size: 239-311;
Related: None;
Template: P37355;
Scope:
 Bacteria
Fusion:
 Nter: None
 Cter: None
Duplicate: None
Plasmid: None
Comments: None
XX
# Revision 1.14 2023/02/17
//