AC   MF_01664;
DC   Protein; auto
TR   HAMAP; MF_01664; -; 1; level=0
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Names: HemeA_synth_type1
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ID   CTAA
DE   RecName: Full=Heme A synthase;
DE            Short=HAS;
DE            EC=1.17.99.9;
DE   AltName: Full=Cytochrome aa3-controlling protein;
GN   Name=ctaA;
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CC   -!- FUNCTION: Catalyzes the conversion of heme O to heme A by two
CC       successive hydroxylations of the methyl group at C8. The first
CC       hydroxylation forms heme I, the second hydroxylation results in an
CC       unstable dihydroxymethyl group, which spontaneously dehydrates,
CC       resulting in the formyl group of heme A.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=2 A + Fe(II)-heme o + H2O = 2 AH2 + Fe(II)-heme a;
CC         Xref=Rhea:RHEA:63388, ChEBI:CHEBI:13193, ChEBI:CHEBI:15377,
CC         ChEBI:CHEBI:17499, ChEBI:CHEBI:60530, ChEBI:CHEBI:61715;
CC         EC=1.17.99.9;
CC       PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:63389;
CC   -!- COFACTOR:
CC       Name=heme b; Xref=ChEBI:CHEBI:60344;
CC   -!- PATHWAY: Porphyrin-containing compound metabolism; heme A biosynthesis;
CC       heme A from heme O: step 1/1.
CC   -!- SUBUNIT: Interacts with CtaB.
CC   -!- SUBCELLULAR LOCATION: Cell membrane; Multi-pass membrane protein.
CC   -!- SIMILARITY: Belongs to the COX15/CtaA family. Type 1 subfamily.
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DR   Pfam; PF02628; COX15-CtaA; 1; trigger=no
DR   General; Transmembrane; -; 8; trigger=yes
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KW   Cell membrane
KW   Heme biosynthesis
KW   Iron
KW   Membrane
KW   Metal-binding
KW   Oxidoreductase
KW   Transmembrane
KW   Transmembrane helix
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GO   GO:0006784; P:heme A biosynthetic process
GO   GO:0005886; C:plasma membrane
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FT   From: CTAA_BACSU (P12946)
FT   BINDING         216
FT                   /ligand="heme"
FT                   /ligand_id="ChEBI:CHEBI:30413"
FT                   /ligand_part="Fe"
FT                   /ligand_part_id="ChEBI:CHEBI:18248"
FT                   /note="axial binding residue"
FT   Condition: H
FT   BINDING         278
FT                   /ligand="heme"
FT                   /ligand_id="ChEBI:CHEBI:30413"
FT                   /ligand_part="Fe"
FT                   /ligand_part_id="ChEBI:CHEBI:18248"
FT                   /note="axial binding residue"
FT   Condition: H
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Size: 297-317;
Related: MF_01665;
Template: P12946;
Scope:
 Bacteria; Bacillota
Fusion:
 Nter: None
 Cter: None
Duplicate: None
Plasmid: None
Comments: COX15/CtaA type 2 subfamily in MF_01665.
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# Revision 1.15 2023/01/13
//