AC   MF_01666;
DC   Protein; auto
TR   HAMAP; MF_01666; -; 1; level=0
XX
Names: 2_Hacid_dh_C_GhrA
XX
ID   GHRA
DE   RecName: Full=Glyoxylate/hydroxypyruvate reductase A;
DE            EC=1.1.1.81;
DE            EC=1.1.1.79;
DE   AltName: Full=2-ketoacid reductase;
GN   Name=ghrA;
XX
CC   -!- FUNCTION: Catalyzes the NADPH-dependent reduction of glyoxylate and
CC       hydroxypyruvate into glycolate and glycerate, respectively.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=glycolate + NADP(+) = glyoxylate + H(+) + NADPH;
CC         Xref=Rhea:RHEA:10992, ChEBI:CHEBI:15378, ChEBI:CHEBI:29805,
CC         ChEBI:CHEBI:36655, ChEBI:CHEBI:57783, ChEBI:CHEBI:58349; EC=1.1.1.79;
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=(R)-glycerate + NAD(+) = 3-hydroxypyruvate + H(+) + NADH;
CC         Xref=Rhea:RHEA:17905, ChEBI:CHEBI:15378, ChEBI:CHEBI:16659,
CC         ChEBI:CHEBI:17180, ChEBI:CHEBI:57540, ChEBI:CHEBI:57945; EC=1.1.1.81;
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=(R)-glycerate + NADP(+) = 3-hydroxypyruvate + H(+) + NADPH;
CC         Xref=Rhea:RHEA:18657, ChEBI:CHEBI:15378, ChEBI:CHEBI:16659,
CC         ChEBI:CHEBI:17180, ChEBI:CHEBI:57783, ChEBI:CHEBI:58349; EC=1.1.1.81;
CC   -!- SUBCELLULAR LOCATION: Cytoplasm.
CC   -!- SIMILARITY: Belongs to the D-isomer specific 2-hydroxyacid
CC       dehydrogenase family. GhrA subfamily.
XX
DR   PROSITE; PS00065; D_2_HYDROXYACID_DH_1; 1; trigger=no
DR   PROSITE; PS00670; D_2_HYDROXYACID_DH_2; 1; trigger=no
DR   PROSITE; PS00671; D_2_HYDROXYACID_DH_3; 1; trigger=no
DR   Pfam; PF02826; 2-Hacid_dh_C; 1; trigger=no
XX
KW   Cytoplasm
KW   NAD
KW   NADP
KW   Oxidoreductase
XX
GO   GO:0016618; F:hydroxypyruvate reductase activity
GO   GO:0030267; F:glyoxylate reductase (NADP+) activity
XX
FT   From: GHRA_ECOLI (P75913)
FT   ACT_SITE        227
FT   Condition: R
FT   ACT_SITE        275
FT                   /note="Proton donor"
FT   Condition: H
XX
Size: 312-325;
Related: None;
Template: P75913;
Scope:
 Bacteria; Enterobacterales
Fusion:
 Nter: None
 Cter: None
Duplicate: None
Plasmid: None
Comments: None
XX
# Revision 1.12 2022/10/07
//