AC   MF_01676;
DC   Protein; auto
TR   HAMAP; MF_01676; -; 1; level=0
XX
Names: AhpD
XX
ID   AHPD
DE   RecName: Full=Alkyl hydroperoxide reductase AhpD;
DE            EC=1.11.1.28;
DE   AltName: Full=Alkylhydroperoxidase AhpD;
GN   Name=ahpD;
XX
CC   -!- FUNCTION: Antioxidant protein with alkyl hydroperoxidase activity.
CC       Required for the reduction of the AhpC active site cysteine residues
CC       and for the regeneration of the AhpC enzyme activity.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=N(6)-[(R)-dihydrolipoyl]-L-lysyl-[lipoyl-carrier protein] + a
CC         hydroperoxide = N(6)-[(R)-lipoyl]-L-lysyl-[lipoyl-carrier protein] +
CC         an alcohol + H2O; Xref=Rhea:RHEA:62636, Rhea:RHEA-COMP:10502,
CC         Rhea:RHEA-COMP:16355, ChEBI:CHEBI:15377, ChEBI:CHEBI:30879,
CC         ChEBI:CHEBI:35924, ChEBI:CHEBI:83099, ChEBI:CHEBI:83100;
CC         EC=1.11.1.28;
case <OC:Actinomycetota>
CC   -!- SUBUNIT: Homotrimer.
end case
CC   -!- SIMILARITY: Belongs to the AhpD family.
XX
DR   Pfam; PF02627; CMD; 1; trigger=no
DR   NCBIfam; TIGR00777; AhpD; 1; trigger=no
DR   NCBIfam; TIGR00778; AhpD_dom; 1; trigger=no
XX
KW   Antioxidant
case <FT:3> or <FT:4>
KW   Disulfide bond
end case
KW   Oxidoreductase
KW   Peroxidase
KW   Redox-active center
XX
GO   GO:0016209; F:antioxidant activity
XX
FT   From: AHPD_MYCTU (P9WQB5)
FT   ACT_SITE        130
FT                   /note="Proton donor"
FT   Condition: C
FT   ACT_SITE        133
FT                   /note="Cysteine sulfenic acid (-SOH) intermediate"
FT   Condition: C
FT   DISULFID        130..133
FT   Condition: C-x*-C
FT   DISULFID        133
FT                   /note="Interchain (with AhpC); in linked form"
FT   Condition: C
XX
Size: 173-194;
Related: None;
Template: P9WQB5;
Scope:
 Bacteria
Fusion:
 Nter: None
 Cter: None
Duplicate: None
Plasmid: None
Comments: None
XX
# Version: 21
# Last updated date: 2025-02-06
# Created date: 2008-10-09
//