AC MF_01678; DC Protein; auto c? or TR HAMAP; MF_01678; -; 1; level=0 XX Names: Salvage_MtnA XX ID MTNA case DE RecName: Full=Putative methylthioribose-1-phosphate isomerase; DE Short=M1Pi; DE Short=MTR-1-P isomerase; DE EC=5.3.1.23; DE AltName: Full=MTNA-like protein; DE Short=aMTNA; DE AltName: Full=S-methyl-5-thioribose-1-phosphate isomerase; else DE RecName: Full=Methylthioribose-1-phosphate isomerase; DE Short=M1Pi; DE Short=MTR-1-P isomerase; DE EC=5.3.1.23; DE AltName: Full=S-methyl-5-thioribose-1-phosphate isomerase; end case case GN Name=mtnA; end case XX CC -!- FUNCTION: Catalyzes the interconversion of methylthioribose-1-phosphate CC (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1-P). CC -!- CATALYTIC ACTIVITY: CC Reaction=S-methyl-5-thio-alpha-D-ribose 1-phosphate = S-methyl-5-thio- CC D-ribulose 1-phosphate; Xref=Rhea:RHEA:19989, ChEBI:CHEBI:58533, CC ChEBI:CHEBI:58548; EC=5.3.1.23; case CC -!- PATHWAY: Amino-acid biosynthesis; L-methionine biosynthesis via salvage CC pathway; L-methionine from S-methyl-5-thio-alpha-D-ribose 1-phosphate: CC step 1/6. end case case CC -!- SUBUNIT: Homodimer. end case CC -!- SIMILARITY: Belongs to the EIF-2B alpha/beta/delta subunits family. CC MtnA subfamily. XX DR Pfam; PF01008; IF-2B; 1; trigger=no DR NCBIfam; TIGR00524; EIF-2B_rel; 1; trigger=no DR NCBIfam; TIGR00512; Salvage_mtnA; 1; trigger=no XX KW Amino-acid biosynthesis KW Isomerase KW Methionine biosynthesis XX GO GO:0046523; F:S-methyl-5-thioribose-1-phosphate isomerase activity GO GO:0019284; P:L-methionine salvage from S-adenosylmethionine XX FT From: MTNA_BACSU (O31662) FT BINDING 51..53 FT /ligand="substrate" FT BINDING 250..251 FT /ligand="substrate" FT ACT_SITE 240 FT /note="Proton donor" FT Condition: D FT BINDING 94 FT /ligand="substrate" FT Condition: R FT BINDING 199 FT /ligand="substrate" FT Condition: Q FT SITE 160 FT /note="Transition state stabilizer" FT Condition: [CS] XX Size: 311-552; Related: MF_02229!; Template: O31662; Scope: Bacteria Archaea Fusion: Nter: Cter: None Duplicate: in PSELT Plasmid: in BRUA4, RHIME, SINMW Comments: None XX # Revision 1.25 2023/06/01 //