AC   MF_01688;
DC   Protein; auto
TR   HAMAP; MF_01688; -; 1; level=0
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Names: Biphenyl_BphD
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ID   BPHD
DE   RecName: Full=2-hydroxy-6-oxo-6-phenylhexa-2,4-dienoate hydrolase;
DE            Short=HOPDA hydrolase;
DE            EC=3.7.1.8;
DE   AltName: Full=2,6-dioxo-6-phenylhexa-3-enoate hydrolase;
GN   Name=bphD;
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CC   -!- FUNCTION: Catalyzes an unusual C-C bond hydrolysis of 2-hydroxy-6-oxo-
CC       6-phenylhexa-2,4-dienoic acid (HOPDA) to produce benzoic acid and 2-
CC       hydroxy-2,4-pentadienoic acid (HPD).
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=2,6-dioxo-6-phenylhexa-3-enoate + H2O = 2-oxopent-4-enoate +
CC         benzoate + H(+); Xref=Rhea:RHEA:17161, ChEBI:CHEBI:11641,
CC         ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:16150,
CC         ChEBI:CHEBI:64675; EC=3.7.1.8;
CC   -!- PATHWAY: Xenobiotic degradation; biphenyl degradation; 2-hydroxy-2,4-
CC       pentadienoate and benzoate from biphenyl: step 4/4.
CC   -!- SUBUNIT: Homodimer.
CC   -!- SIMILARITY: Belongs to the AB hydrolase superfamily. BphD family.
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DR   Pfam; PF00561; Abhydrolase_1; 1; trigger=no
DR   NCBIfam; TIGR03343; Biphenyl_bphD; 1; trigger=no
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KW   Aromatic hydrocarbons catabolism
KW   Hydrolase
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GO   GO:0018771; F:2-hydroxy-6-oxonona-2,4-dienedioate hydrolase activity
GO   GO:0019439; P:aromatic compound catabolic process
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FT   From: BPHD_PARXL (P47229)
FT   BINDING         42..43
FT                   /ligand="substrate"
FT   Condition: G-G
FT   ACT_SITE        112
FT   Condition: S
FT   ACT_SITE        265
FT                   /note="Proton acceptor"
FT   Condition: H
FT   BINDING         51
FT                   /ligand="substrate"
FT   Condition: N
FT   BINDING         111
FT                   /ligand="substrate"
FT   Condition: [KN]
FT   BINDING         180
FT                   /ligand="substrate"
FT   Condition: [ST]
FT   BINDING         190
FT                   /ligand="substrate"
FT   Condition: R
FT   BINDING         266
FT                   /ligand="substrate"
FT   Condition: W
FT   SITE            112
FT                   /note="Transition state stabilizer"
FT   Condition: S
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Size: 286-286;
Related: None;
Template: P47229;
Scope:
 Bacteria; Pseudomonadota
Fusion:
 Nter: None
 Cter: None
Duplicate: None
Plasmid: in BURCE, POLNA
Comments: None
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# Revision 1.19 2023/06/01
//