AC   MF_01703;
DC   Protein; auto
TR   PROSITE; PS51239; MSBA; 1; level=0
XX
Names: ABC_ATPase_TM_MsbA
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ID   MSBA
DE   RecName: Full=ATP-dependent lipid A-core flippase;
DE            EC=7.5.2.6;
DE   AltName: Full=Lipid A export ATP-binding/permease protein MsbA;
GN   Name=msbA;
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CC   -!- FUNCTION: Involved in lipopolysaccharide (LPS) biosynthesis.
CC       Translocates lipid A-core from the inner to the outer leaflet of the
CC       inner membrane. Transmembrane domains (TMD) form a pore in the inner
CC       membrane and the ATP-binding domain (NBD) is responsible for energy
CC       generation.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=ATP + H2O + lipid A-core oligosaccharideSide 1 = ADP +
CC         phosphate + lipid A-core oligosaccharideSide 2.; EC=7.5.2.6;
CC   -!- SUBUNIT: Homodimer.
case not defined <Property:Membrane> or <Property:Membrane=1>
CC   -!- SUBCELLULAR LOCATION: Cell membrane; Multi-pass membrane protein.
else case <Property:Membrane=2>
CC   -!- SUBCELLULAR LOCATION: Cell inner membrane; Multi-pass membrane protein.
end case
CC   -!- DOMAIN: In MsbA the ATP-binding domain (NBD) and the transmembrane
CC       domain (TMD) are fused.
CC   -!- SIMILARITY: Belongs to the ABC transporter superfamily. Lipid exporter
CC       (TC 3.A.1.106) family.
XX
DR   Pfam; PF00005; ABC_tran; 1; trigger=no
DR   Pfam; PF00664; ABC_membrane; 1; trigger=no
DR   NCBIfam; TIGR02203; MsbA_lipidA; 1; trigger=no
DR   PROSITE; PS50929; ABC_TM1F; 1; trigger=yes
DR   PROSITE; PS00211; ABC_TRANSPORTER_1; 1; trigger=no
DR   PROSITE; PS50893; ABC_TRANSPORTER_2; 1; trigger=yes
DR   General; Transmembrane; -; 5-6; trigger=yes
XX
GO   GO:0006869; P:lipid transport
GO   GO:0034040; F:ATPase-coupled lipid transmembrane transporter activity
case <OC:Bacteria>
GO   GO:0005886; C:plasma membrane
end case
XX
KW   ATP-binding
case defined <Property:Membrane> and <Property:Membrane=2>
KW   Cell inner membrane
end case
KW   Cell membrane
KW   Translocase
KW   Lipid transport
KW   Membrane
KW   Nucleotide-binding
KW   Transmembrane
KW   Transmembrane helix
KW   Transport
XX
Size: 572-675;
Related: PRU01700;
Template: P60752;
Scope:
 Bacteria; Pseudomonadota
Fusion:
 Nter: None
 Cter: None
Duplicate: None
Plasmid: None
Comments: None
XX
# Revision 1.23 2023/06/01
//