AC   MF_01710;
DC   Protein; auto
TR   PROSITE; PS51246; CBIO; 1; level=0
XX
Names: ABC_ATPase_CbiO_EcfA
XX
case <OC:Pseudomonadota>
ID   CBIO
DE   RecName: Full=Cobalt import ATP-binding protein CbiO;
DE            EC=7.-.-.-;
DE   AltName: Full=Energy-coupling factor transporter ATP-binding protein CbiO;
DE            Short=ECF transporter A component CbiO;
GN   Name=cbiO;
else
ID   ECFA
DE   RecName: Full=Energy-coupling factor transporter ATP-binding protein EcfA;
DE            Short=ECF transporter A component EcfA;
DE            EC=7.-.-.-;
GN   Name=ecfA;
end case
XX
case <OC:Pseudomonadota>
CC   -!- FUNCTION: Part of the energy-coupling factor (ECF) transporter complex
CC       CbiMNOQ involved in cobalt import. Presumably responsible for energy
CC       coupling to the transport system.
CC   -!- PATHWAY: Cofactor biosynthesis; adenosylcobalamin biosynthesis.
CC   -!- SUBUNIT: Forms an energy-coupling factor (ECF) transporter complex
CC       composed of an ATP-binding protein (A component, CbiO), a transmembrane
CC       protein (T component, CbiQ) and 2 possible substrate-capture proteins
CC       (S components, CbiM and CbiN) of unknown stoichimetry.
else
CC   -!- FUNCTION: ATP-binding (A) component of a common energy-coupling factor
CC       (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF
CC       transporter provides the energy necessary to transport a number of
CC       different substrates.
CC   -!- SUBUNIT: Forms a stable energy-coupling factor (ECF) transporter
CC       complex composed of 2 membrane-embedded substrate-binding proteins (S
CC       component), 2 ATP-binding proteins (A component) and 2 transmembrane
CC       proteins (T component).
end case
case not defined <Property:Membrane> or <Property:Membrane=1>
CC   -!- SUBCELLULAR LOCATION: Cell membrane; Peripheral membrane protein.
else case <Property:Membrane=2>
CC   -!- SUBCELLULAR LOCATION: Cell inner membrane; Peripheral membrane protein.
end case
case <OC:Pseudomonadota>
CC   -!- SIMILARITY: Belongs to the ABC transporter superfamily. Cobalt importer
CC       (TC 3.A.1.18.1) family.
else
CC   -!- SIMILARITY: Belongs to the ABC transporter superfamily. Energy-coupling
CC       factor EcfA family.
end case
XX
DR   Pfam; PF00005; ABC_tran; 1; trigger=no
DR   NCBIfam; TIGR01166; CbiO; 1; trigger=no
DR   PROSITE; PS00211; ABC_TRANSPORTER_1; 1; trigger=no
DR   PROSITE; PS50893; ABC_TRANSPORTER_2; 1; trigger=yes
XX
case <OC:Pseudomonadota>
GO   GO:0006824; P:cobalt ion transport
GO   GO:0015087; F:cobalt ion transmembrane transporter activity
end case
GO   GO:0005886; C:plasma membrane
XX
KW   ATP-binding
KW   Nucleotide-binding
case defined <Property:Membrane> and <Property:Membrane=2>
KW   Cell inner membrane
end case
KW   Cell membrane
KW   Membrane
KW   Transport
case <OC:Pseudomonadota>
KW   Cobalt
KW   Cobalt transport
KW   Cobalamin biosynthesis
KW   Ion transport
end case
KW   Translocase
XX
Size: 200-591;
Related: PRU01700;
Template: Q05596; O68106; A2RI01; Q03ZL6; Q035B2; Q9X1Z1; Q9WY65; Q5M243; Q5M244;
Scope:
 Bacteria
 Archaea
Fusion:
 Nter: None
 Cter: None
Duplicate: in BACAH, BACAN, BACC1, BACCR, BACCZ, HALH5, BACHK, BACLD, BACSU,
 CLOAB, CLOD6, CLONN, CLOP1, CLOPE, CLOPS, CLOTE, ACET2, ENTFA, FUSNN, GEOKA,
 LACAC, LEVBA, LACP3, LACDA, LACDB, LACGA, LACJO, LACLA, LACLM, LACLS, LACPL,
 LIGS1, LATSS, LEUMM, LISIN, LISMF, LISMO, LISW6, MESFL, METHJ, MYCCT, MYCGA,
 MYCGE, MESH2, MESH7, MESHJ, MESM1, MYCMS, MYCPN, MYCPU, MYCS5, OCEIH, OENOB,
 SPIKU, STAA3, STAA8, STAAB, STAAC, STAAM, STAAN, STAAR, STAAS, STAAW, STAEQ,
 STAES, STAHJ, STAS1, STRA1, STRA3, STRA5, STRMU, STRP1, STRP2, STRP3, STRP6,
 STRP8, STRPB, STRPC, STRPD, STRPF, STRPG, STRPM, STRPN, STRR6, STRSV, STRT1,
 STRT2, STRTD, SYMTH, CALS4, UREPA
Plasmid: None
Comments: In Pseudomonadota is part of a dedicated cobalt transporter;
 RHOCB is experimentally a member of this family but does not fit the
 PROSITE profile. In Bacillota (and probably other bacteria and archaea)
 this is an ABC subunit of an energy-coupling transporter that imports more
 than 1 substrate. See:
 PubMed=18931129; DOI=10.1128/JB.01208-08;
 Rodionov D.A., Hebbeln P., Eudes A., ter Beek J., Rodionova I.A.,
 Erkens G.B., Slotboom D.J., Gelfand M.S., Osterman A.L., Hanson A.D.,
 Eitinger T.;
 "A novel class of modular transporters for vitamins in prokaryotes.";
 J. Bacteriol. 191:42-51(2009).
 The subunit composition has been determined to be 2S:2T:A1:A2 PMID:23359690.
XX
# Revision 1.41 2023/06/01
//