AC   MF_01720;
DC   Protein; auto
c?   <OC:Bacteria> and not <OC:Pseudomonadales>
TR   PROSITE; PS51267; MACB; 1; level=0
XX
Names: ABC_ATPase_TM_MacB
XX
ID   MACB
DE   RecName: Full=Macrolide export ATP-binding/permease protein MacB;
DE            EC=7.6.2.-;
GN   Name=macB;
XX
case <OC:Gammaproteobacteria>
CC   -!- FUNCTION: Part of the tripartite efflux system MacAB-TolC. MacB is a
CC       non-canonical ABC transporter that contains transmembrane domains
CC       (TMD), which form a pore in the inner membrane, and an ATP-binding
CC       domain (NBD), which is responsible for energy generation. Confers
CC       resistance against macrolides.
CC   -!- SUBUNIT: Homodimer. Part of the tripartite efflux system MacAB-TolC,
CC       which is composed of an inner membrane transporter, MacB, a periplasmic
CC       membrane fusion protein, MacA, and an outer membrane component, TolC.
CC       The complex forms a large protein conduit and can translocate molecules
CC       across both the inner and outer membranes. Interacts with MacA.
CC   -!- SUBCELLULAR LOCATION: Cell inner membrane; Multi-pass membrane protein.
else case defined <Property:Membrane> and <Property:Membrane=2>
CC   -!- FUNCTION: Non-canonical ABC transporter that contains transmembrane
CC       domains (TMD), which form a pore in the inner membrane, and an ATP-
CC       binding domain (NBD), which is responsible for energy generation.
CC       Confers resistance against macrolides.
CC   -!- SUBUNIT: Homodimer.
CC   -!- SUBCELLULAR LOCATION: Cell inner membrane; Multi-pass membrane protein.
else
CC   -!- FUNCTION: Non-canonical ABC transporter that contains transmembrane
CC       domains (TMD), which form a pore in the membrane, and an ATP-binding
CC       domain (NBD), which is responsible for energy generation. Confers
CC       resistance against macrolides.
CC   -!- SUBUNIT: Homodimer.
CC   -!- SUBCELLULAR LOCATION: Cell membrane; Multi-pass membrane protein.
end case
CC   -!- SIMILARITY: Belongs to the ABC transporter superfamily. Macrolide
CC       exporter (TC 3.A.1.122) family.
XX
DR   Pfam; PF00005; ABC_tran; 1; trigger=no
DR   Pfam; PF02687; FtsX; 1; trigger=no
DR   PROSITE; PS00211; ABC_TRANSPORTER_1; 1; trigger=no
DR   PROSITE; PS50893; ABC_TRANSPORTER_2; 1; trigger=yes
DR   General; Transmembrane; -; 3-5; trigger=yes
XX
GO   GO:0008559; F:ABC-type xenobiotic transporter activity
GO   GO:1990961; P:xenobiotic detoxification by transmembrane export across the plasma membrane
GO   GO:0005886; C:plasma membrane
XX
KW   ATP-binding
case <OC:Gammaproteobacteria> or (defined <Property:Membrane> and <Property:Membrane=2>)
KW   Cell inner membrane
end case
KW   Nucleotide-binding
KW   Transport
KW   Antibiotic resistance
KW   Translocase
KW   Membrane
KW   Cell membrane
KW   Transmembrane
KW   Transmembrane helix
XX
Size: 640-715;
Related: PRU01700;
Template: P75831;
Scope:
 Bacteria
Fusion:
 Nter: None
 Cter: None
Duplicate: in ECOLI, PSEF5, PSEPF, PSESM, PSEU2, YERPA, YERPE, YERPN, YERPS
Plasmid: in AGRFC, ECOLI
Comments: None
XX
# Revision 1.27 2023/06/20
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