AC   MF_01800;
DC   Protein; auto
TR   HAMAP; MF_01800; -; 1; level=0
XX
Names: MukB
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ID   MUKB
DE   RecName: Full=Chromosome partition protein MukB;
DE   AltName: Full=Structural maintenance of chromosome-related protein;
GN   Name=mukB;
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CC   -!- FUNCTION: Plays a central role in chromosome condensation, segregation
CC       and cell cycle progression. Functions as a homodimer, which is
CC       essential for chromosome partition. Involved in negative DNA
CC       supercoiling in vivo, and by this means organize and compact
CC       chromosomes. May achieve or facilitate chromosome segregation by
CC       condensation DNA from both sides of a centrally located replisome
CC       during cell division.
CC   -!- SUBUNIT: Homodimerization via its hinge domain. Binds to DNA via its C-
CC       terminal region. Interacts, and probably forms a ternary complex, with
CC       MukE and MukF via its C-terminal region. The complex formation is
CC       stimulated by calcium or magnesium. Interacts with tubulin-related
CC       protein FtsZ.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm, nucleoid. Note=Restricted to the
CC       nucleoid region.
CC   -!- DOMAIN: The hinge domain, which separates the large intramolecular
CC       coiled coil regions, allows the homodimerization, forming a V-shaped
CC       homodimer.
CC   -!- SIMILARITY: Belongs to the SMC family. MukB subfamily.
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DR   Pfam; PF04310; MukB; 1; trigger=no
DR   General; Coiled_coil; -; 1-unlimited; trigger=yes
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KW   Cytoplasm
KW   Cell cycle
KW   Cell division
KW   Chromosome partition
KW   DNA-binding
KW   DNA condensation
KW   ATP-binding
KW   Nucleotide-binding
KW   Coiled coil
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GO   GO:0005737; C:cytoplasm
GO   GO:0003677; F:DNA binding
GO   GO:0005524; F:ATP binding
GO   GO:0006260; P:DNA replication
GO   GO:0007059; P:chromosome segregation
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FT   From: MUKB_ECOLI (P22523)
FT   BINDING         34..41
FT                   /ligand="ATP"
FT                   /ligand_id="ChEBI:CHEBI:30616"
FT   Condition: [AG]-x(4)-G-K-[ST]
FT   REGION          666..783
FT                   /note="Flexible hinge"
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Size: 1479-1510;
Related: MF_01801;
Template: P22523;
Scope:
 Bacteria; Gammaproteobacteria
Fusion:
 Nter: None
 Cter: None
Duplicate: None
Plasmid: None
Comments: Despite a low sequence conservation, mukB is strongly related to smc
 (MF_01801), and displays the same function.
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# Revision 1.27 2022/11/19
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