AC   MF_01813;
DC   Protein; auto
c?   <OC:Bacteria> or <OC:Archaea>
TR   HAMAP; MF_01813; -; 1; level=0
XX
Names: MenG_UbiE_methyltr
XX
case <OC:Pseudomonadota>
ID   UBIE
DE   RecName: Full=Ubiquinone/menaquinone biosynthesis C-methyltransferase UbiE;
DE            EC=2.1.1.163;
DE            EC=2.1.1.201;
DE   AltName: Full=2-methoxy-6-polyprenyl-1,4-benzoquinol methylase;
DE   AltName: Full=Demethylmenaquinone methyltransferase;
GN   Name=ubiE;
else
ID   MENG
DE   RecName: Full=Demethylmenaquinone methyltransferase;
DE            EC=2.1.1.163;
GN   Name=menG;
end case
XX
case <OC:Pseudomonadota>
CC   -!- FUNCTION: Methyltransferase required for the conversion of
CC       demethylmenaquinol (DMKH2) to menaquinol (MKH2) and the conversion of
CC       2-polyprenyl-6-methoxy-1,4-benzoquinol (DDMQH2) to 2-polyprenyl-3-
CC       methyl-6-methoxy-1,4-benzoquinol (DMQH2).
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=a 2-demethylmenaquinol + S-adenosyl-L-methionine = a
CC         menaquinol + H(+) + S-adenosyl-L-homocysteine; Xref=Rhea:RHEA:42640,
CC         Rhea:RHEA-COMP:9539, Rhea:RHEA-COMP:9563, ChEBI:CHEBI:15378,
CC         ChEBI:CHEBI:18151, ChEBI:CHEBI:55437, ChEBI:CHEBI:57856,
CC         ChEBI:CHEBI:59789; EC=2.1.1.163;
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=a 2-methoxy-6-all-trans-polyprenyl-1,4-benzoquinol + S-
CC         adenosyl-L-methionine = a 6-methoxy-3-methyl-2-all-trans-polyprenyl-
CC         1,4-benzoquinol + H(+) + S-adenosyl-L-homocysteine;
CC         Xref=Rhea:RHEA:28286, Rhea:RHEA-COMP:10858, Rhea:RHEA-COMP:10859,
CC         ChEBI:CHEBI:15378, ChEBI:CHEBI:57856, ChEBI:CHEBI:59789,
CC         ChEBI:CHEBI:84166, ChEBI:CHEBI:84167; EC=2.1.1.201;
CC   -!- PATHWAY: Quinol/quinone metabolism; menaquinone biosynthesis;
CC       menaquinol from 1,4-dihydroxy-2-naphthoate: step 2/2.
CC   -!- PATHWAY: Cofactor biosynthesis; ubiquinone biosynthesis.
else
CC   -!- FUNCTION: Methyltransferase required for the conversion of
CC       demethylmenaquinol (DMKH2) to menaquinol (MKH2).
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=a 2-demethylmenaquinol + S-adenosyl-L-methionine = a
CC         menaquinol + H(+) + S-adenosyl-L-homocysteine; Xref=Rhea:RHEA:42640,
CC         Rhea:RHEA-COMP:9539, Rhea:RHEA-COMP:9563, ChEBI:CHEBI:15378,
CC         ChEBI:CHEBI:18151, ChEBI:CHEBI:55437, ChEBI:CHEBI:57856,
CC         ChEBI:CHEBI:59789; EC=2.1.1.163;
CC   -!- PATHWAY: Quinol/quinone metabolism; menaquinone biosynthesis;
CC       menaquinol from 1,4-dihydroxy-2-naphthoate: step 2/2.
end case
CC   -!- SIMILARITY: Belongs to the class I-like SAM-binding methyltransferase
CC       superfamily. MenG/UbiE family.
XX
DR   Pfam; PF01209; Ubie_methyltran; 1; trigger=no
DR   NCBIfam; TIGR01934; MenG_MenH_UbiE; 1; trigger=no
DR   PROSITE; PS51608; SAM_MT_UBIE; 1; trigger=no
DR   PROSITE; PS01183; UBIE_1; 1; trigger=no
DR   PROSITE; PS01184; UBIE_2; 1; trigger=no
XX
KW   Menaquinone biosynthesis
case <OC:Pseudomonadota>
KW   Ubiquinone biosynthesis
end case
KW   S-adenosyl-L-methionine
KW   Transferase
KW   Methyltransferase
XX
case <OC:Pseudomonadota>
GO   GO:0008425; F:2-polyprenyl-6-methoxy-1,4-benzoquinone methyltransferase activity
GO   GO:0009060; P:aerobic respiration
end case
GO   GO:0009234; P:menaquinone biosynthetic process
XX
FT   From: COQ5_YEAST (P49017)
FT   BINDING         179..180
FT                   /ligand="S-adenosyl-L-methionine"
FT                   /ligand_id="ChEBI:CHEBI:59789"
FT   Condition: [ND]-x
FT   BINDING         122
FT                   /ligand="S-adenosyl-L-methionine"
FT                   /ligand_id="ChEBI:CHEBI:59789"
FT   Condition: [ST]
FT   BINDING         148
FT                   /ligand="S-adenosyl-L-methionine"
FT                   /ligand_id="ChEBI:CHEBI:59789"
FT   Condition: D
FT   BINDING         197
FT                   /ligand="S-adenosyl-L-methionine"
FT                   /ligand_id="ChEBI:CHEBI:59789"
FT   Condition: S
XX
Size: 220-352;
Related: MF_03192!; MF_01982!;
Template: P31113; P0A887; P49017;
Scope:
 Bacteria
 Archaea
Fusion:
 Nter: None
 Cter: None
Duplicate: None
Plasmid: None
Comments: None
XX
# Revision 1.34 2023/06/01
//