AC   MF_01816;
DC   Protein; auto
TR   HAMAP; MF_01816; -; 1; level=0
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Names: Recomb_XerS
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ID   XERS
DE   RecName: Full=Tyrosine recombinase XerS;
GN   Name=xerS;
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CC   -!- FUNCTION: Site-specific tyrosine recombinase, which acts by catalyzing
CC       the cutting and rejoining of the recombining DNA molecules. Essential
CC       to convert dimers of the bacterial chromosome into monomers to permit
CC       their segregation at cell division.
CC   -!- ACTIVITY REGULATION: FtsK is required for recombination.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm.
CC   -!- SIMILARITY: Belongs to the 'phage' integrase family. XerS subfamily.
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DR   Pfam; PF00589; Phage_integrase; 1; trigger=no
DR   Pfam; PF02899; Phage_integr_N; 1; trigger=no
DR   PROSITE; PS51900; CB; 1; trigger=yes
DR   PROSITE; PS51898; TYR_RECOMBINASE; 1; trigger=yes
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KW   Cell cycle
KW   Cell division
KW   Chromosome partition
KW   Cytoplasm
KW   DNA integration
KW   DNA recombination
KW   DNA-binding
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GO   GO:0009037; F:tyrosine-based site-specific recombinase activity
GO   GO:0007059; P:chromosome segregation
GO   GO:0006310; P:DNA recombination
GO   GO:0005737; C:cytoplasm
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FT   From: XERS_LACLM (A2RKP9)
FT   ACT_SITE        210
FT   Condition: R
FT   ACT_SITE        234
FT   Condition: K
FT   ACT_SITE        306
FT   Condition: H
FT   ACT_SITE        309
FT   Condition: R
FT   ACT_SITE        332
FT   Condition: H
FT   ACT_SITE        341
FT                   /note="O-(3'-phospho-DNA)-tyrosine intermediate"
FT   Condition: Y
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Size: 340-375;
Related: None;
Template: A2RKP9; Q7ZAK7;
Scope:
 Bacteria; Streptococcaceae
Fusion:
 Nter: None
 Cter: None
Duplicate: None
Plasmid: None
Comments: XerS is an alternative Xer recombination machinery found in Streptococci and Lactococci.
 It is related to Xerc/XerD tyrosine recombinases of E.coli.
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# Revision 1.25 2019/11/19
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