AC   MF_01821;
DC   Protein; auto
TR   HAMAP; MF_01821; -; 1; level=0
XX
Names: Helicase_RapA
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ID   RAPA
DE   RecName: Full=RNA polymerase-associated protein RapA;
DE            EC=3.6.4.-;
DE   AltName: Full=ATP-dependent helicase HepA;
GN   Name=rapA;
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CC   -!- FUNCTION: Transcription regulator that activates transcription by
CC       stimulating RNA polymerase (RNAP) recycling in case of stress
CC       conditions such as supercoiled DNA or high salt concentrations.
CC       Probably acts by releasing the RNAP, when it is trapped or immobilized
CC       on tightly supercoiled DNA. Does not activate transcription on linear
CC       DNA. Probably not involved in DNA repair.
CC   -!- SUBUNIT: Interacts with the RNAP. Has a higher affinity for the core
CC       RNAP than for the holoenzyme. Its ATPase activity is stimulated by
CC       binding to RNAP.
CC   -!- SIMILARITY: Belongs to the SNF2/RAD54 helicase family. RapA subfamily.
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DR   Pfam; PF00271; Helicase_C; 1; trigger=no
DR   Pfam; PF00176; SNF2_N; 1; trigger=no
DR   PROSITE; PS00690; DEAH_ATP_HELICASE; 1; trigger=no
DR   PROSITE; PS51192; HELICASE_ATP_BIND_1; 1; trigger=yes
DR   PROSITE; PS51194; HELICASE_CTER; 1; trigger=yes
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KW   Transcription
KW   Transcription regulation
KW   Hydrolase
KW   Helicase
KW   Activator
KW   ATP-binding
KW   Nucleotide-binding
KW   DNA-binding
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GO   GO:0004386; F:helicase activity
GO   GO:0005524; F:ATP binding
GO   GO:0006355; P:regulation of DNA-templated transcription
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FT   From: RAPA_ECOLI (P60240)
FT   BINDING         177..184
FT                   /ligand="ATP"
FT                   /ligand_id="ChEBI:CHEBI:30616"
FT   Condition: D-x-x-G-x-G-K-T
FT   MOTIF           280..283
FT                   /note="DEAH box"
FT   Condition: D-E-[ALIV]-H
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Size: 556-1170;
Related: None;
Template: P60240;
Scope:
 Bacteria; Gammaproteobacteria
Fusion:
 Nter: None
 Cter: None
Duplicate: None
Plasmid: None
Comments: None
XX
# Revision 1.25 2022/11/19
//