AC   MF_01824;
DC   Protein; auto
TR   HAMAP; MF_01824; -; 1; level=0
XX
Names: PdxS
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ID   PDXS
DE   RecName: Full=Pyridoxal 5'-phosphate synthase subunit PdxS;
DE            Short=PLP synthase subunit PdxS;
DE            EC=4.3.3.6;
DE   AltName: Full=Pdx1;
GN   Name=pdxS;
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CC   -!- FUNCTION: Catalyzes the formation of pyridoxal 5'-phosphate from ribose
CC       5-phosphate (RBP), glyceraldehyde 3-phosphate (G3P) and ammonia. The
CC       ammonia is provided by the PdxT subunit. Can also use ribulose 5-
CC       phosphate and dihydroxyacetone phosphate as substrates, resulting from
CC       enzyme-catalyzed isomerization of RBP and G3P, respectively.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=aldehydo-D-ribose 5-phosphate + D-glyceraldehyde 3-phosphate +
CC         L-glutamine = H(+) + 3 H2O + L-glutamate + phosphate + pyridoxal 5'-
CC         phosphate; Xref=Rhea:RHEA:31507, ChEBI:CHEBI:15377,
CC         ChEBI:CHEBI:15378, ChEBI:CHEBI:29985, ChEBI:CHEBI:43474,
CC         ChEBI:CHEBI:58273, ChEBI:CHEBI:58359, ChEBI:CHEBI:59776,
CC         ChEBI:CHEBI:597326; EC=4.3.3.6;
CC   -!- PATHWAY: Cofactor biosynthesis; pyridoxal 5'-phosphate biosynthesis.
CC   -!- SUBUNIT: In the presence of PdxT, forms a dodecamer of heterodimers.
CC   -!- SIMILARITY: Belongs to the PdxS/SNZ family.
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DR   Pfam; PF00218; IGPS; 1; trigger=no
DR   Pfam; PF01680; SOR_SNZ; 1; trigger=no
DR   PIRSF; PIRSF029271; Pdx1; 1; trigger=no
DR   NCBIfam; TIGR00343; TIGR00343; 1; trigger=no
DR   PROSITE; PS01235; PDXS_SNZ_1; 1; trigger=no
DR   PROSITE; PS51129; PDXS_SNZ_2; 1; trigger=no
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KW   Lyase
KW   Pyridoxal phosphate
KW   Schiff base
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GO   GO:0036381; F:pyridoxal 5'-phosphate synthase (glutamine hydrolysing) activity
GO   GO:0042823; P:pyridoxal phosphate biosynthetic process
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FT   From: PDXS_PYRHO (O59080)
FT   BINDING         278..279
FT                   /ligand="D-ribose 5-phosphate"
FT                   /ligand_id="ChEBI:CHEBI:78346"
FT   Condition: G-S
FT   ACT_SITE        87
FT                   /note="Schiff-base intermediate with D-ribose 5-phosphate"
FT   Condition: K
FT   BINDING         30
FT                   /ligand="D-ribose 5-phosphate"
FT                   /ligand_id="ChEBI:CHEBI:78346"
FT   Condition: D
FT   BINDING         159
FT                   /ligand="D-ribose 5-phosphate"
FT                   /ligand_id="ChEBI:CHEBI:78346"
FT   Condition: G
FT   BINDING         171
FT                   /ligand="D-glyceraldehyde 3-phosphate"
FT                   /ligand_id="ChEBI:CHEBI:59776"
FT   Condition: [RKQ]
FT   BINDING         257
FT                   /ligand="D-ribose 5-phosphate"
FT                   /ligand_id="ChEBI:CHEBI:78346"
FT   Condition: G
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Size: 280-338;
Related: None;
Template: P37527; Q9WYU4; O59080; Q5L3Y2;
Scope:
 Bacteria
 Archaea
Fusion:
 Nter: None
 Cter: None
Duplicate: None
Plasmid: None
Comments: None
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# Revision 1.26 2023/06/01
//