AC   MF_01840;
DC   Protein; auto
TR   HAMAP; MF_01840; -; 1; level=0
XX
Names: AcsF
XX
ID   ACSF
case <OC:Bacteria> and not <OC:Cyanobacteriota>
DE   RecName: Full=Aerobic magnesium-protoporphyrin IX monomethyl ester [oxidative] cyclase;
DE            Short=Aerobic Mg-protoporphyrin IX monomethyl ester oxidative cyclase;
DE            EC=1.14.13.81;
else case <OC:Cyanobacteriota> or <OG:Chloroplast>
DE   RecName: Full=Magnesium-protoporphyrin IX monomethyl ester [oxidative] cyclase;
DE            Short=Mg-protoporphyrin IX monomethyl ester oxidative cyclase;
DE            EC=1.14.13.81;
else
DE   RecName: Full=Probable magnesium-protoporphyrin IX monomethyl ester [oxidative] cyclase;
DE            Short=Mg-protoporphyrin IX monomethyl ester oxidative cyclase;
DE            EC=1.14.13.81;
end case
GN   Name=acsF;
XX
CC   -!- FUNCTION: Catalyzes the formation of the isocyclic ring in chlorophyll
CC       biosynthesis. Mediates the cyclase reaction, which results in the
CC       formation of divinylprotochlorophyllide (Pchlide) characteristic of all
CC       chlorophylls from magnesium-protoporphyrin IX 13-monomethyl ester
CC       (MgPMME).
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=2 H(+) + Mg-protoporphyrin IX 13-monomethyl ester + 3 NADPH +
CC         3 O2 = 3,8-divinyl protochlorophyllide a + 5 H2O + 3 NADP(+);
CC         Xref=Rhea:RHEA:33235, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378,
CC         ChEBI:CHEBI:15379, ChEBI:CHEBI:57783, ChEBI:CHEBI:58349,
CC         ChEBI:CHEBI:58632, ChEBI:CHEBI:60491; EC=1.14.13.81;
CC   -!- COFACTOR:
CC       Name=Fe cation; Xref=ChEBI:CHEBI:24875;
case <OC:Bacteria> and not <OC:Cyanobacteriota>
CC   -!- PATHWAY: Porphyrin-containing compound metabolism; bacteriochlorophyll
CC       biosynthesis (light-independent).
end case
case <OC:Cyanobacteriota> or <OG:Chloroplast>
CC   -!- PATHWAY: Porphyrin-containing compound metabolism; chlorophyll
CC       biosynthesis (light-independent).
end case
case <OG:Chloroplast>
CC   -!- SUBCELLULAR LOCATION: Plastid, chloroplast.
end case
CC   -!- SIMILARITY: Belongs to the AcsF family.
XX
DR   Pfam; PF02915; Rubrerythrin; 1; trigger=no
DR   NCBIfam; TIGR02029; AcsF; 1; trigger=no
XX
case <OC:Bacteria> and not <OC:Cyanobacteriota>
KW   Bacteriochlorophyll biosynthesis
end case
KW   Chlorophyll biosynthesis
KW   Iron
KW   Metal-binding
KW   NADP
KW   Oxidoreductase
KW   Photosynthesis
XX
case <OC:Bacteria> and not <OC:Cyanobacteriota>
GO   GO:0030494; P:bacteriochlorophyll biosynthetic process
end case
case <OC:Cyanobacteriota> or <OG:Chloroplast>
GO   GO:0015995; P:chlorophyll biosynthetic process
end case
GO   GO:0005506; F:iron ion binding
GO   GO:0048529; F:magnesium-protoporphyrin IX monomethyl ester (oxidative) cyclase activity
GO   GO:0015979; P:photosynthesis
case <OG:Chloroplast>
GO   GO:0009507; C:chloroplast
end case
XX
Size: 299-390;
Related: None;
Template: P0DJN9;
Scope:
 Bacteria
 Bacteria; Cyanobacteriota
 Bacteria; Alphaproteobacteria
 Bacteria; Betaproteobacteria
 Plastid
Fusion:
 Nter: None
 Cter: None
Duplicate: in NOSS1, THEVB, SYNY3
Plasmid: None
Comments: None
XX
# Revision 1.26 2023/06/01
//